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ATP8B3 Knockout Cell Lines

Gene: ATP8B3

Official Full Name: ATPase phospholipid transporting 8B3provided by HGNC

Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of aminophospholipid-transporting ATPases. The aminophospholipid translocases transport phosphatidylserine and phosphatidylethanolamine from one side of a bilayer to the other. This gene encodes member 3 of phospholipid-transporting ATPase 8B; other members of this protein family are located on chromosomes 1, 15 and 18. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO23474 ATP8B3 Knockout cell line (HeLa) Human ATP8B3 1:3~1:6 Negative Online Inquiry
KO23475 ATP8B3 Knockout cell line (HCT 116) Human ATP8B3 1:2~1:4 Negative Online Inquiry
KO23476 ATP8B3 Knockout cell line (A549) Human ATP8B3 1:3~1:4 Negative Online Inquiry

Background

ATP8B3 Gene Knockout Cell Lines are advanced model systems designed to facilitate the study of the ATP8B3 gene, which is critical for phospholipid transport and metabolism in eukaryotic cells. These cell lines have been genetically modified to disrupt the ATP8B3 gene through targeted genome editing techniques, such as CRISPR-Cas9, allowing researchers to investigate the gene's role in cellular processes, disease mechanisms, and therapeutic responses.

The primary function of ATP8B3 involves regulating the distribution of phospholipids within cellular membranes, which is critical for maintaining membrane integrity and function. By studying these knockout cell lines, researchers can gain insights into the consequences of ATP8B3 deficiency, shedding light on its involvement in various pathophysiological conditions, including liver and metabolic disorders. The mechanistic pathways elucidated through these studies can significantly inform drug development and therapeutic strategies.

In the context of scientific research and clinical applications, ATP8B3 Gene Knockout Cell Lines are invaluable tools for dissecting complex biological pathways and screening potential pharmacological agents. Compared to traditional wild-type cell lines, these knockout models present a unique advantage by mimicking disease-specific scenarios, allowing for more accurate modeling of physiological responses and drug interactions.

The specific advantages of our ATP8B3 Gene Knockout Cell Lines include their robust genetic validation, reproducibility in experimental outcomes, and compatibility with various experimental protocols, such as high-throughput screenings and gene expression analyses. This inherent reliability, combined with comprehensive support and technical assistance provided by our company, ensures that researchers can significantly advance their work without the common pitfalls associated with less characterized cell models.

Our expertise in cell line development and genetic engineering positions us as leaders in providing high-quality biological products that meet the diverse needs of researchers and clinicians alike. By choosing ATP8B3 Gene Knockout Cell Lines, you are investing in a powerful resource that will enhance your research capabilities and contribute to meaningful advancements in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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