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ATP11C Knockout Cell Lines

Gene: ATP11C

Official Full Name: ATPase phospholipid transporting 11C (ATP11C blood group)provided by HGNC

Gene Summary: Enables phosphatidylethanolamine flippase activity and phosphatidylserine flippase activity. Involved in phospholipid translocation. Located in endoplasmic reticulum and plasma membrane. Part of phospholipid-translocating ATPase complex. Implicated in X-linked congenital hemolytic anemia. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19557 ATP11C Knockout cell line (HeLa) Human ATP11C 1:3~1:6 Negative Online Inquiry
KO19558 ATP11C Knockout cell line (HCT 116) Human ATP11C 1:2~1:4 Negative Online Inquiry
KO19559 ATP11C Knockout cell line (HEK293) Human ATP11C 1:3~1:6 Negative Online Inquiry
KO19560 ATP11C Knockout cell line (A549) Human ATP11C 1:3~1:4 Negative Online Inquiry

Background

ATP11C Gene Knockout Cell Lines are genetically engineered cell lines designed to specifically eliminate the expression of the ATP11C gene, which encodes an important P-type ATPase involved in phospholipid transport across cell membranes. By knocking out this gene, researchers can elucidate the role of ATP11C in various physiological processes, such as cellular membrane dynamics, ion homeostasis, and phospholipid metabolism. The knockout mechanism is achieved through advanced CRISPR-Cas9 technology, allowing precise and efficient gene editing that results in loss-of-function mutations, thereby enabling detailed studies into the consequences of ATP11C deficiency.

The importance of these cell lines in scientific research cannot be overstated. They serve as vital tools in the exploration of various pathophysiological conditions, including their roles in immunity, cancer biology, and metabolic disorders. Understanding the function of ATP11C may aid in the development of therapeutic strategies for diseases where membrane transport processes are disrupted. Moreover, ATP11C knockout models can provide insight into the development of drug resistance and sensitivity within cancer biology, thereby guiding future pharmacological studies.

What sets ATP11C Gene Knockout Cell Lines apart from alternative models is their consistency and specificity. Prepared with rigorous quality control and validation protocols, these cell lines minimize the variability seen in primary cell cultures and offer a reliable platform for reproducible experiments. They are optimized for ease of use in various assay formats, including high-throughput screening, which is crucial for accelerating research timelines.

These knockout cell lines are indispensable for researchers and clinicians seeking to unravel complex biological mechanisms and to innovate therapeutic approaches. Their robust design and the profound implications for translational research make them a worthy investment in any laboratory focused on cutting-edge biological studies.

Our company prides itself on delivering high-quality biological products, supported by a strong foundation of scientific expertise and innovation in gene editing technologies. We are committed to empowering researchers with the tools they need to drive discovery and enhance human health through rigorous scientific exploration.

Please note that all services are for research use only. Not intended for any clinical use.

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