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ATOH8 Knockout Cell Lines

Gene: ATOH8

Official Full Name: atonal bHLH transcription factor 8provided by HGNC

Gene Summary: Enables DNA-binding transcription factor activity and E-box binding activity. Involved in several processes, including positive regulation of SMAD protein signal transduction; positive regulation of endothelial cell differentiation; and regulation of gene expression. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO24487 ATOH8 Knockout cell line (HeLa) Human ATOH8 1:3~1:6 Negative Online Inquiry
KO24488 ATOH8 Knockout cell line (A549) Human ATOH8 1:3~1:4 Negative Online Inquiry

Background

ATOH8 Gene Knockout Cell Lines are specifically engineered cellular models that facilitate the study of the Atoh8 gene, which plays a critical role in various biological processes, including nerve development and differentiation in the central nervous system. These knockout cell lines are created using advanced CRISPR-Cas9 gene-editing technology, leading to a precise deletion of the ATOH8 gene, thereby allowing for unambiguous evaluation of its physiological functions and downstream effects.

The primary function of these cell lines is to enable researchers to investigate the role of ATOH8 in cellular mechanisms such as neural differentiation, apoptosis, and response to oxidative stress. By eliminating the ATOH8 gene, researchers can observe phenotypic changes and alterations in molecular pathways that are crucial for understanding diseases related to neural deficiencies and developmental disorders. This gene knockout model serves as a robust platform for drug discovery and therapeutic development, highlighting its significance in both academic and clinical research settings.

One of the key advantages of ATOH8 Gene Knockout Cell Lines is their specificity and reliance on precise gene editing, which mitigates off-target effects commonly associated with other gene manipulation techniques. Compared to traditional knockdown approaches, such as RNA interference, knockout models provide a more definitive analysis of gene function, enabling clearer insights into the role of ATOH8 in health and disease.

For researchers and clinicians, the value of these cell lines lies in their contribution to elucidating the underlying mechanisms of neurological conditions, paving the way for innovative therapeutic strategies. With our expertise in genetic engineering and commitment to advancing biological research, our company offers high-quality ATOH8 Gene Knockout Cell Lines that empower the scientific community to make significant strides in both research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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