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ATG10 Knockout Cell Lines

Gene: ATG10

Official Full Name: autophagy related 10provided by HGNC

Gene Summary: Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19597 ATG10 Knockout cell line (HeLa) Human ATG10 1:3~1:6 Negative Online Inquiry
KO19598 ATG10 Knockout cell line (HCT 116) Human ATG10 1:2~1:4 Negative Online Inquiry
KO19599 ATG10 Knockout cell line (HEK293) Human ATG10 1:3~1:6 Negative Online Inquiry
KO19600 ATG10 Knockout cell line (A549) Human ATG10 1:3~1:4 Negative Online Inquiry

Background

ATG10 Gene Knockout Cell Lines are specialized cellular models engineered to lack the ATG10 gene, which plays a crucial role in the autophagy process—an essential intracellular degradation pathway responsible for maintaining cellular homeostasis. These cell lines are instrumental in elucidating the mechanisms underlying autophagy and its impact on cellular processes, including metabolism, stress response, and cell survival.

The primary function of ATG10 is to facilitate the conjugation of the ATG12 protein to ATG5, a necessary step in forming autophagosomes, which ultimately lead to cargo degradation and recycling. By utilizing ATG10 Gene Knockout Cell Lines, researchers can accurately assess the consequences of disrupted autophagic flux and investigate the downstream effects related to various diseases, including neurodegenerative disorders, cancer, and infectious diseases.

The scientific importance of these cell lines lies in their applicability to both fundamental research and therapeutic development. In the realm of research, they provide a robust platform to study the roles of autophagy in disease progression and to test the efficacy of potential autophagy-modulating therapies. In clinical settings, insights gained from utilizing these lines may aid in identifying novel biomarkers for disease outcomes and enhancing patient treatment strategies.

One of the main advantages of ATG10 Gene Knockout Cell Lines is their specificity and reliability. Unlike traditional wild-type models, these knockout lines eliminate confounding factors related to autophagic activity; thus, they enable clear and concise interpretations of experimental results. This specificity allows researchers to draw meaningful conclusions and develop targeted interventions.

For researchers and clinicians seeking to deepen their understanding of cellular mechanisms and therapeutic potentials related to autophagy, ATG10 Gene Knockout Cell Lines are indispensable tools that provide clarity and precision. By integrating these innovative cell lines into their studies, users can significantly enhance the value of their research outputs and clinical findings.

Our company prides itself on delivering high-quality biological products that support cutting-edge research. With expertise in genetic engineering and cell line development, we are committed to providing exceptional tools like ATG10 Gene Knockout Cell Lines to empower the scientific community in their quest for breakthroughs in health and disease.

Please note that all services are for research use only. Not intended for any clinical use.

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