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ATF1 Knockout Cell Lines

Gene: ATF1

Official Full Name: activating transcription factor 1provided by HGNC

Gene Summary: This gene encodes an activating transcription factor, which belongs to the ATF subfamily and bZIP (basic-region leucine zipper) family. It influences cellular physiologic processes by regulating the expression of downstream target genes, which are related to growth, survival, and other cellular activities. This protein is phosphorylated at serine 63 in its kinase-inducible domain by serine/threonine kinases, cAMP-dependent protein kinase A, calmodulin-dependent protein kinase I/II, mitogen- and stress-activated protein kinase and cyclin-dependent kinase 3 (cdk-3). Its phosphorylation enhances its transactivation and transcriptional activities, and enhances cell transformation. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in angiomatoid fibrous histiocytoma and clear cell sarcoma. This gene has a pseudogene on chromosome 6. [provided by RefSeq, Aug 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO01462 ATF1 Knockout cell line(LoVo) Human ATF1 Negative Online Inquiry
KO19611 ATF1 Knockout cell line (HeLa) Human ATF1 1:3~1:6 Negative Online Inquiry
KO19612 ATF1 Knockout cell line (HCT 116) Human ATF1 1:2~1:4 Negative Online Inquiry
KO19613 ATF1 Knockout cell line (HEK293) Human ATF1 1:3~1:6 Negative Online Inquiry
KO19614 ATF1 Knockout cell line (A549) Human ATF1 1:3~1:4 Negative Online Inquiry

Background

ATF1 Gene Knockout Cell Lines are genetically modified cell lines designed to specifically lack the Activating Transcription Factor 1 (ATF1) gene. This gene plays a critical role in cellular processes such as stress response, metabolism, and apoptosis. By employing techniques such as CRISPR-Cas9 gene editing, researchers can create precise deletions of the ATF1 gene, allowing rigorous study of its biological functions and regulatory mechanisms. The loss of ATF1 provides an invaluable model for exploring the implications of gene knockout scenarios in cellular signaling pathways and disease states.

The key function of these cell lines lies in their capacity to elucidate the role of ATF1 in various pathological conditions, including cancer, metabolic disorders, and neurodegenerative diseases. Researchers can investigate how the absence of ATF1 shifts cellular behaviors, alters gene expression profiles, and influences responses to therapeutic agents. This capacity to model gene function is crucial for understanding the underlying mechanisms that drive disease and developing targeted treatments.

Scientifically, ATF1 Gene Knockout Cell Lines offer high relevance in both basic research and translational medicine. They provide a unique opportunity to explore fundamental questions about gene regulation and cellular adaptability in a controlled environment, making them essential for advancing therapeutic strategies. Moreover, the ability to use CRISPR technology ensures that researchers achieve high specificity and efficiency in their experiments.

What sets our ATF1 Gene Knockout Cell Lines apart from alternative products is our commitment to quality and reproducibility. Each cell line is thoroughly validated for consistent performance, with a strong focus on maintaining authenticity and genetic integrity. Additionally, our comprehensive technical support and documentation enable researchers to seamlessly integrate these models into their studies.

For researchers and clinicians alike, the ATF1 Gene Knockout Cell Lines represent a valuable tool that enhances the understanding of gene function and disease mechanisms, ultimately contributing to the development of novel interventions. Our company specializes in providing high-quality biological products, and our expertise in genetic engineering ensures that our customers receive cutting-edge solutions tailored to their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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