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ASPDH Knockout Cell Lines

Gene: ASPDH

Official Full Name: aspartate dehydrogenase domain containingprovided by HGNC

Gene Summary: Predicted to enable NADP binding activity and aspartate dehydrogenase activity. Predicted to be involved in NAD biosynthetic process. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19630 ASPDH Knockout cell line (HEK293) Human ASPDH 1:3~1:6 Negative Online Inquiry

Background

ASPDH Gene Knockout Cell Lines are engineered cell models designed to specifically disrupt the activity of the aspartate-semialdehyde dehydrogenase (ASPDH) gene. This gene encodes an enzyme crucial for lysine and threonine biosynthesis in various microorganisms, and its knockout facilitates the study of metabolic pathways associated with amino acid synthesis. By utilizing CRISPR-Cas9 genome editing technology, these cell lines present researchers with advanced tools to investigate gene function, metabolic regulation, and the underlying mechanisms of various diseases related to amino acid metabolism.

The primary function of ASPDH Gene Knockout Cell Lines revolves around providing insights into metabolic dysregulation and its consequent effects on cellular physiology. By eliminating ASPDH expression, researchers can observe the resulting phenotypic changes, enabling the identification of potential therapeutic targets in metabolic disorders, cancer, and neurodegenerative diseases. Additionally, these cell lines can serve as platforms for testing small-molecule inhibitors or novel compounds that can restore normal cellular function, thereby bridging the gap between basic research and clinical therapeutics.

The scientific importance of ASPDH Gene Knockout Cell Lines cannot be overstated, as they offer distinct advantages over traditional cell models, including high reproducibility, specific targeting of the gene of interest, and the elimination of off-target effects often seen with other gene-editing techniques. These features position ASPDH knockout lines as superior alternatives for researchers focused on elucidating the roles of specific genes in metabolic pathways.

The product's unique offering lies in its customizable nature, allowing users to select cell types that best suit their specific research needs. Our ASPDH Gene Knockout Cell Lines are validated for use across multiple research domains, making them a versatile addition to any laboratory.

In conclusion, investing in ASPDH Gene Knockout Cell Lines provides researchers and clinicians with powerful tools to advance their understanding of metabolic processes and develop innovative therapeutic strategies. Backed by our extensive expertise in biological product development and a commitment to quality, we ensure that our cell lines meet rigorous scientific standards, empowering our customers to achieve groundbreaking discoveries.

Please note that all services are for research use only. Not intended for any clinical use.

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