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ASIP Knockout Cell Lines

Gene: ASIP

Official Full Name: agouti signaling proteinprovided by HGNC

Gene Summary: In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38899 ASIP Knockout cell line (HEK293) Human ASIP 1:3~1:6 Negative Online Inquiry

Background

ASIP Gene Knockout Cell Lines are genetically modified cellular models engineered to lack the ASIP gene, which encodes the agouti signaling protein. This protein is crucial in various biological processes, particularly in pigmentation, energy balance, and metabolic regulation. By utilizing these knockout cell lines, researchers can observe the effects of ASIP depletion on signaling pathways and physiological responses, providing invaluable insights into obesity, diabetes, and other metabolic disorders.

The primary function of these cell lines lies in their ability to mimic the absence of the ASIP gene, allowing for a clearer understanding of its role in cellular processes. The knockout model serves as a powerful tool for studying gene function and interaction with other signaling molecules. Researchers can utilize these cells to investigate the downstream effects of ASIP loss, including alterations in melanin production and changes in fat storage mechanisms, ultimately elucidating the gene's contributions to metabolic health.

The scientific importance of ASIP Gene Knockout Cell Lines extends into both basic research and clinical applications. In vitro studies can lead to the identification of novel therapeutic targets and the development of potential interventions for metabolic conditions. These models are especially valuable for drug screening and the investigation of gene therapy possibilities.

Compared to traditional models, ASIP Gene Knockout Cell Lines offer specificity and consistency that enhance experimental reproducibility and validity. They present a focused avenue for dissecting the biological effects of ASIP, which is often confounded by the many functions of wild-type alleles.

Researchers and clinicians can greatly benefit from employing these gene knockout models, as they unlock the potential for groundbreaking discoveries in metabolic research and therapeutic developments. With the rise in metabolic disorders globally, having access to precise models like these is crucial for advancing treatment strategies.

Our company is dedicated to providing high-quality genetic research tools, ensuring that our ASIP Gene Knockout Cell Lines are thoroughly validated and backed by our commitment to innovation in biological sciences. We strive to empower researchers with the tools they require to push the boundaries of discovery in the field.

Please note that all services are for research use only. Not intended for any clinical use.

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