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ARTN Knockout Cell Lines

Gene: ARTN

Official Full Name: arteminprovided by HGNC

Gene Summary: This gene encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma. [provided by RefSeq, Aug 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33633 ARTN Knockout cell line (HeLa) Human ARTN 1:3~1:6 Negative Online Inquiry
KO33634 ARTN Knockout cell line (HCT 116) Human ARTN 1:2~1:4 Negative Online Inquiry
KO33635 ARTN Knockout cell line (HEK293) Human ARTN 1:3~1:6 Negative Online Inquiry

Background

ARTN Gene Knockout Cell Lines are a specialized biological product designed to facilitate the study of the art neurotrophic factor (ARTN) gene's role in various cellular processes. These cell lines are invaluable tools for researchers seeking to elucidate the molecular mechanisms underlying neurodevelopmental and neurodegenerative disorders. By employing CRISPR-Cas9 gene-editing technology, ARTN Gene Knockout Cell Lines enable precise gene disruption, allowing for the investigation of ARTN's functions in cellular signaling, survival, and differentiation pathways.

The key mechanism by which these cell lines operate lies in the strategic deletion of the ARTN gene, abolishing its expression and allowing researchers to observe resultant phenotypic changes. This approach provides insights into the pathways modulated by ARTN, particularly in neuronal health and disease states, further illuminating potential therapeutic targets for conditions such as Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's disease.

In clinical and research settings, these knockout cell lines are critical for drug discovery and preclinical studies. They offer scientists the ability to develop and test candidate therapies targeting ARTN-mediated pathways in a controllable environment, fostering innovation in neuroprotective strategies. Compared to traditional wild-type cell lines, ARTN Gene Knockout Cell Lines present a refined model system that reduces variability, enhancing the reproducibility of experimental results.

The unique selling points of these knockout cell lines include their robust genetic validation, user-friendly design, and compatibility with high-throughput screening methods, which streamline research workflows. Researchers and clinicians will find exceptional value in these cell lines, as they represent a leap forward in elucidating ARTN-related mechanisms and facilitating the development of targeted therapies.

With extensive experience in the production of genetically modified organisms and a commitment to quality, our company stands at the forefront of biotechnological innovation. We offer a comprehensive selection of tools that empower the scientific community to accelerate breakthroughs in biological research, ensuring that our partners are equipped with the highest caliber products for their investigations.

Please note that all services are for research use only. Not intended for any clinical use.

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