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ARL5B Knockout Cell Lines

Gene: ARL5B

Official Full Name: ARF like GTPase 5Bprovided by HGNC

Gene Summary: ARL5B (ARL8) belongs to a family of proteins that are structurally similar to ADP-ribosylation factors (ARFs; see MIM 103180). ARLs and ARFs are part of the RAS superfamily of regulatory GTPases.[supplied by OMIM, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO27553 ARL5B Knockout cell line (HeLa) Human ARL5B 1:3~1:6 Negative Online Inquiry
KO27554 ARL5B Knockout cell line (HCT 116) Human ARL5B 1:2~1:4 Negative Online Inquiry
KO27555 ARL5B Knockout cell line (HEK293) Human ARL5B 1:3~1:6 Negative Online Inquiry
KO27556 ARL5B Knockout cell line (A549) Human ARL5B 1:3~1:4 Negative Online Inquiry

Background

ARL5B Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the function of the ARL5B gene, which encodes a member of the ADP-ribosylation factor (ARF) family of small GTPases. These cell lines have been engineered to harbor a complete knockout of ARL5B, facilitating the exploration of its physiological roles, intracellular signaling pathways, and potential implications in various diseases, including cancer and neurodegeneration.

The key mechanism of action involves the disruption of ARL5B gene expression, allowing researchers to examine the downstream effects of its absence on cellular mechanisms, such as vesicular trafficking, cell migration, and cytoskeletal dynamics. By providing a controlled experimental environment, these knockout cell lines enable more precise investigations into the gene's contributions to cellular homeostasis and its interplay with other signaling molecules.

From a scientific standpoint, the ARL5B Gene Knockout Cell Lines serve as invaluable tools in both basic research and drug discovery efforts, enhancing our understanding of GTPase biology and its clinical relevance. Their applications extend to unraveling the molecular mechanisms underlying various pathologies, facilitating the development of targeted therapies that can modulate ARL5B-related pathways.

One of the distinctive advantages of our ARL5B Gene Knockout Cell Lines lies in their rigorous validation and characterization, ensuring that researchers receive high-quality models that replicate the specific knockout phenotypes necessary for reliable data collection. Unlike other alternatives that may lack robust documentation of gene disruption or functional consequences, our product offers comprehensive support, including experimental protocols and detailed guidance, to empower researchers in their investigations.

For researchers and clinicians seeking to deepen their understanding of ARL5B and its associated pathways, these cell lines represent a unique and powerful asset. At [Your Company Name], we pride ourselves on our expertise in creating and supplying high-quality biological products that support cutting-edge scientific research and contribute to advancements in health and medicine.

Please note that all services are for research use only. Not intended for any clinical use.

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