Gene: ARID4B
Official Full Name: AT-rich interaction domain 4Bprovided by HGNC
Gene Summary: This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO22229 | ARID4B Knockout cell line (HeLa) | Human | ARID4B | 1:3~1:6 | Negative | Online Inquiry |
KO22230 | ARID4B Knockout cell line (HCT 116) | Human | ARID4B | 1:2~1:4 | Negative | Online Inquiry |
KO22231 | ARID4B Knockout cell line (HEK293) | Human | ARID4B | 1:3~1:6 | Negative | Online Inquiry |
KO22232 | ARID4B Knockout cell line (A549) | Human | ARID4B | 1:3~1:4 | Negative | Online Inquiry |
ARID4B Gene Knockout Cell Lines are genetically engineered cells specifically designed to facilitate the study of the ARID4B gene's role in biological processes. These knockout cell lines have undergone targeted gene editing to disrupt the ARID4B genetic locus, enabling researchers to investigate the gene's function in a controlled environment. By utilizing CRISPR-Cas9 technology, our product ensures precise and efficient gene knockout, providing a reliable model for examining ARID4B's involvement in various cellular pathways, including differentiation, proliferation, and oncogenesis.
The primary function of ARID4B involves its role as a transcriptional regulator, impacting chromatin remodeling and gene expression. Disruption of ARID4B can lead to significant alterations in cellular behavior, making these cell lines invaluable for high-throughput screening and functional assays in both basic and applied research. They allow scientists to delve into the cellular consequences of ARID4B deficiency, particularly in cancer biology, where aberrant ARID4B expression has been implicated in tumorigenesis.
These knockout cell lines stand out due to their specificity and reliability, providing significant advantages over alternative approaches. Unlike traditional cell models that may exhibit variable expression, our ARID4B knockout cell lines offer consistent and reproducible results, critical for establishing robust scientific findings. Their ease of use minimizes the time and resources typically required in early-stage research, enhancing productivity in the lab.
For researchers and clinicians alike, the value of these cell lines is underscored by the growing emphasis on personalized and targeted therapies. The insights gained from studying ARID4B could lead to novel therapeutic strategies for ARID4B-related diseases, providing a path toward innovative treatments.
In collaboration with leading experts in genetic engineering and cellular biology, our company ensures that ARID4B Gene Knockout Cell Lines not only meet but exceed the highest standards of scientific rigor. With a commitment to advancing biological research, we offer comprehensive support to help you maximize the utility of our products in your studies.
Please note that all services are for research use only. Not intended for any clinical use.
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