Gene: ARID4A
Official Full Name: AT-rich interaction domain 4Aprovided by HGNC
Gene Summary: The protein encoded by this gene is a ubiquitously expressed nuclear protein. It binds directly, with several other proteins, to retinoblastoma protein (pRB) which regulates cell proliferation. pRB represses transcription by recruiting the encoded protein. This protein, in turn, serves as a bridging molecule to recruit HDACs and, in addition, provides a second HDAC-independent repression function. The encoded protein possesses transcriptional repression activity. Multiple alternatively spliced transcripts have been observed for this gene, although not all transcript variants have been fully described. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO35684 | ARID4A Knockout cell line (HeLa) | Human | ARID4A | 1:3~1:6 | Negative | Online Inquiry |
KO35685 | ARID4A Knockout cell line (HCT 116) | Human | ARID4A | 1:2~1:4 | Negative | Online Inquiry |
KO35686 | ARID4A Knockout cell line (HEK293) | Human | ARID4A | 1:3~1:6 | Negative | Online Inquiry |
KO35687 | ARID4A Knockout cell line (A549) | Human | ARID4A | 1:3~1:4 | Negative | Online Inquiry |
ARID4A Gene Knockout Cell Lines are specialized cellular models created to facilitate the study of the ARID4A gene's role in various biological processes and disease states. Using advanced CRISPR/Cas9 technology, these cell lines exhibit complete knockout of the ARID4A gene, enabling researchers to explore its functions and implications in mechanisms such as transcriptional regulation, cell proliferation, and tumorigenesis. The absence of ARID4A can shed light on its influence in cancer development, as it has been implicated in several malignancies.
The primary function of ARID4A involves chromatin remodeling and gene expression modulation, acting as a transcriptional co-regulator. By using these knockout cell lines, scientists can dissect the molecular pathways governed by ARID4A and how its dysregulation contributes to disease pathology. This knowledge is imperative for developing targeted therapies and understanding tumor biology.
In research and clinical settings, ARID4A Gene Knockout Cell Lines are invaluable tools for drug discovery and testing, as they allow for the evaluation of therapeutic strategies that target ARID4A-related pathways. Compared to traditional overexpression or wild-type models, these knockout cell lines provide a more accurate representation of the gene's functional absence, enabling true mechanistic insights.
The unique selling points of our ARID4A Gene Knockout Cell Lines include their validated knockout efficiency, the ease of use in various assays, and their capability to model human disease more faithfully than immortalized cell lines. Importantly, researchers can rely on these cell lines to yield reproducible results essential for hypothesis validation.
For researchers and clinicians focusing on cancer biology and therapeutic development, the ARID4A Gene Knockout Cell Lines represent a cutting-edge resource that significantly enhances the understanding of complex biological systems. Our company stands at the forefront of biotechnological innovation, dedicated to providing high-quality biological products that empower scientific research and foster advancements in health and medicine.
Please note that all services are for research use only. Not intended for any clinical use.
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