Gene: ARHGEF26
Official Full Name: Rho guanine nucleotide exchange factor 26provided by HGNC
Gene Summary: This gene encodes a member of the Rho-guanine nucleotide exchange factor (Rho-GEF) family. These proteins regulate Rho GTPases by catalyzing the exchange of GDP for GTP. The encoded protein specifically activates RhoG and plays a role in the promotion of macropinocytosis. Underexpression of the encoded protein may be a predictive marker of chemoresistant disease. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28370 | ARHGEF26 Knockout cell line (HeLa) | Human | ARHGEF26 | 1:3~1:6 | Negative | Online Inquiry |
KO28371 | ARHGEF26 Knockout cell line (HCT 116) | Human | ARHGEF26 | 1:2~1:4 | Negative | Online Inquiry |
KO28372 | ARHGEF26 Knockout cell line (HEK293) | Human | ARHGEF26 | 1:3~1:6 | Negative | Online Inquiry |
KO28373 | ARHGEF26 Knockout cell line (A549) | Human | ARHGEF26 | 1:3~1:4 | Negative | Online Inquiry |
ARHGEF26 Gene Knockout Cell Lines represent a significant advancement in the study of cellular signaling pathways and their implications in health and disease. These specialized cell lines are engineered to have a complete deletion of the ARHGEF26 gene, which is known to play a pivotal role in regulating Rho GTPases and influencing various cellular processes such as cytoskeletal dynamics, cell adhesion, and migration. By enabling researchers to examine cellular responses and functions in the absence of ARHGEF26, these knockout models facilitate a better understanding of the gene's contributions to cellular behavior under normal and pathological conditions.
The primary function of ARHGEF26 involves mediating signals that are crucial for cell shape and movement, making these knockout cell lines valuable tools for investigating signaling cascades affecting cancer metastasis, immune response, and other diseases characterized by altered cell motility. Their capabilities extend to various applications in research settings, including drug development, cellular biology studies, and the exploration of genetic interactions that contribute to complex diseases.
Compared to alternative models, ARHGEF26 Gene Knockout Cell Lines offer unparalleled specificity in studying the role of this gene without confounding factors, allowing researchers to obtain more precise data and insights. Such targeted research empowers scientific investigations that require a thorough understanding of cellular mechanisms, providing clearer pathways for therapeutic interventions.
The value of ARHGEF26 Gene Knockout Cell Lines lies in their ability to bridge the gap between fundamental research and potential clinical applications, enabling advancements in treatment strategies for diseases driven by dysregulated cellular functions. This product not only enhances the efficacy of experimental designs for researchers but also augments therapeutic explorations for clinicians seeking to harness the power of gene-targeted therapies.
Developed by our company, which possesses deep expertise in genetic engineering and cell line development, ARHGEF26 Gene Knockout Cell Lines exemplify our commitment to providing high-quality biological products that propel scientific discovery and innovation in healthcare.
Please note that all services are for research use only. Not intended for any clinical use.
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