Gene: ARHGEF19
Official Full Name: Rho guanine nucleotide exchange factor 19provided by HGNC
Gene Summary: Guanine nucleotide exchange factors (GEFs) such as ARHGEF19 accelerate the GTPase activity of Rho GTPases (see RHOA, MIM 165390).[supplied by OMIM, Dec 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO26782 | ARHGEF19 Knockout cell line (HeLa) | Human | ARHGEF19 | 1:3~1:6 | Negative | Online Inquiry |
KO26783 | ARHGEF19 Knockout cell line (HCT 116) | Human | ARHGEF19 | 1:2~1:4 | Negative | Online Inquiry |
KO26784 | ARHGEF19 Knockout cell line (A549) | Human | ARHGEF19 | 1:3~1:4 | Negative | Online Inquiry |
ARHGEF19 Gene Knockout Cell Lines are genetically modified cell lines specifically designed to study the function of the ARHGEF19 gene, which plays a crucial role in regulating signaling pathways that influence cellular processes including migration, adhesion, and overall cellular dynamics. By creating a knockout of the ARHGEF19 gene, researchers can more effectively assess the physiological roles and regulatory mechanisms mediated by this gene in various biological contexts.
The key function of these knockout cell lines lies in their ability to provide a controlled environment for the analysis of ARHGEF19's contributions to G protein signaling and actin cytoskeleton organization. The knockout mechanism facilitates the observation of phenotypic changes in response to various stimuli, allowing for insights into the gene's involvement in pathological conditions, such as cancer metastasis and other cellular dysfunctions. This is particularly valuable in academic and clinical research settings where understanding the underlying genetic factors of disease is crucial.
The scientific importance of ARHGEF19 Gene Knockout Cell Lines extends well beyond basic research; they are integral to drug discovery processes and the development of targeted therapies. Their application has shown promise in elucidating new therapeutic pathways and identifying potential biomarkers.
Compared to alternatives, such as overexpression or knockdown systems, the absolute knockout of the gene provides a more definitive insight into its biological role, ensuring researchers can effectively delineate the impacts of ARHGEF19 absence on cellular behavior. Additionally, these cell lines are rigorously validated for consistency and reliability, which enhances the reproducibility of experimental results.
Ultimately, ARHGEF19 Gene Knockout Cell Lines offer researchers and clinicians a unique tool to explore gene function in a well-defined genetic background, illuminating critical pathways that could lead to novel intervention strategies. Our company draws upon extensive expertise in genetic engineering and cellular biology, ensuring that our products meet the highest standards of scientific rigor and provide innovative solutions for researchers seeking to advance their work in gene function and therapeutic development.
Please note that all services are for research use only. Not intended for any clinical use.
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