Home / ARHGEF1 Knockout Cell Lines

ARHGEF1 Knockout Cell Lines

Gene: ARHGEF1

Official Full Name: Rho guanine nucleotide exchange factor 1provided by HGNC

Gene Summary: Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. Multiple alternatively spliced transcript variants have been found for this gene, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2008]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO33553 ARHGEF1 Knockout cell line (HeLa) Human ARHGEF1 1:3~1:6 Negative Online Inquiry
KO33554 ARHGEF1 Knockout cell line (HCT 116) Human ARHGEF1 1:2~1:4 Negative Online Inquiry
KO33555 ARHGEF1 Knockout cell line (HEK293) Human ARHGEF1 1:3~1:6 Negative Online Inquiry
KO33556 ARHGEF1 Knockout cell line (A549) Human ARHGEF1 1:3~1:4 Negative Online Inquiry

Background

ARHGEF1 Gene Knockout Cell Lines are specialized biological research tools designed to facilitate the study of the ARHGEF1 gene, known to play a significant role in cellular signaling and cytoskeletal organization. These cell lines are engineered to lack functional ARHGEF1 protein, enabling researchers to explore the gene's involvement in various physiological processes and its implications in diseases such as cancer and cardiovascular disorders.

The primary function of ARHGEF1 is to act as a guanine nucleotide exchange factor (GEF), which activates Rho GTPases, key regulators of the actin cytoskeleton and cell motility. By using ARHGEF1 knockout cell lines, scientists can examine the downstream effects of GEF activity, allowing for a deeper understanding of cell behavior in both normal and disease states. These models facilitate the dissection of complex signaling pathways, opening avenues for the development of targeted therapeutics.

The scientific importance of these cell lines extends to their application in both fundamental research and clinical settings. They serve as indispensable tools for identifying novel drug targets, elucidating the mechanisms of drug resistance, and assessing therapeutic efficacy in personalized medicine. As biological research increasingly focuses on gene-function relationships, the availability of ARHGEF1 knockout cell lines offers unparalleled insights that are pivotal for advancing our understanding of various pathologies.

What sets ARHGEF1 Gene Knockout Cell Lines apart from other available models is their specificity and reliability. These lines are derived from well-characterized parental cell types, ensuring reproducibility and consistency across experiments. Additionally, the precise knockout of the ARHGEF1 gene minimizes off-target effects, allowing researchers to generate more accurate data.

For researchers and clinicians alike, ARHGEF1 Gene Knockout Cell Lines represent a valuable resource for pioneering studies that bridge the gap between basic and applied science. Their capacity to uncover the intricacies of cellular signaling pathways contributes to the advancement of therapeutics aimed at disease intervention.

As an industry leader in the production of high-quality biological models, our company is committed to providing researchers with reliable tools that enhance scientific discovery and innovation. Our expertise in developing genetically modified cell lines ensures that you receive products backed by rigorous validation and quality assurance, supporting your research endeavors with confidence.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.