Home / ARHGAP44 Knockout Cell Lines

ARHGAP44 Knockout Cell Lines

Gene: ARHGAP44

Official Full Name: Rho GTPase activating protein 44provided by HGNC

Gene Summary: Enables phospholipid binding activity. Predicted to be involved in several processes, including modification of dendritic spine; negative regulation of Rac protein signal transduction; and regulation of plasma membrane bounded cell projection organization. Located in leading edge membrane. Implicated in acquired immunodeficiency syndrome and skin melanoma. Biomarker of hepatocellular carcinoma and lung carcinoma. [provided by Alliance of Genome Resources, Apr 2025]

Get A Quote
Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO32531 ARHGAP44 Knockout cell line (HeLa) Human ARHGAP44 1:3~1:6 Negative Online Inquiry
KO32532 ARHGAP44 Knockout cell line (HCT 116) Human ARHGAP44 1:2~1:4 Negative Online Inquiry
KO32533 ARHGAP44 Knockout cell line (HEK293) Human ARHGAP44 1:3~1:6 Negative Online Inquiry
KO32534 ARHGAP44 Knockout cell line (A549) Human ARHGAP44 1:3~1:4 Negative Online Inquiry

Background

ARHGAP44 Gene Knockout Cell Lines are precisely engineered cellular models designed to investigate the functional implications of the ARHGAP44 gene, which encodes a member of the Rho GTPase-activating protein family. This product facilitates the disruption of the ARHGAP44 gene, effectively creating loss-of-function models that are invaluable for studying its role in various cellular processes, including cytoskeletal dynamics, cell migration, and signal transduction.

The core mechanism of these knockout cell lines hinges on CRISPR/Cas9 technology, granting researchers the capability to induce targeted genomic alterations. By effectively disrupting the ARHGAP44 gene, these cell lines enable the examination of the protein’s contributions to disease pathogenesis, providing insights into mechanisms underlying cancer, neurodegeneration, and other related disorders. In addition, the inherent adaptability of these cell lines allows for the investigation of ARHGAP44's interactions within complex signaling networks, potentially identifying novel therapeutic targets.

From a scientific perspective, the ARHGAP44 Gene Knockout Cell Lines serve as essential tools in both basic and applied research contexts, empowering scientists to delineate the gene's function within cellular environments. Compared to traditional knockdown approaches, these knockout models provide a more complete ablation of gene function, which leads to clearer interpretations of phenotypic outcomes and biological behaviors.

Notably, these cell lines come with significant advantages, including enhanced reproducibility and ease of use in high-throughput screening assays. Researchers can achieve more accurate experimental results, leading to faster discoveries. The specificity of targeting ARHGAP44 also minimizes off-target effects common with other genetic manipulation techniques.

Investing in ARHGAP44 Gene Knockout Cell Lines offers researchers and clinicians unparalleled value, enhancing their ability to uncover the complexities of gene function and contributing to the development of targeted therapies. Our company brings extensive expertise in creating high-fidelity biological products, ensuring that each cell line is validated for genetic integrity and performance, thereby supporting your research goals with unmatched reliability and precision.

Please note that all services are for research use only. Not intended for any clinical use.

Get a free quote

If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.

0

There is no product in your cart.