Gene: AREG
Official Full Name: amphiregulinprovided by HGNC
Gene Summary: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). The protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells, and it inhibits the growth of certain aggressive carcinoma cell lines. It also functions in mammary gland, oocyte and bone tissue development. This gene is associated with a psoriasis-like skin phenotype, and is also associated with other pathological disorders, including various types of cancers and inflammatory conditions. [provided by RefSeq, Apr 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO10942 | AREG Knockout cell line (HeLa) | Human | AREG | 1:3~1:6 | Negative | Online Inquiry |
KO10943 | AREG Knockout cell line (HCT 116) | Human | AREG | 1:2~1:4 | Negative | Online Inquiry |
KO10944 | AREG Knockout cell line (A549) | Human | AREG | 1:3~1:4 | Negative | Online Inquiry |
AREG Gene Knockout Cell Lines are genetically engineered cell models specifically designed to eliminate the expression of the amphiregulin (AREG) gene. This product represents a significant advancement in the realm of molecular biology by providing researchers with essential tools to investigate the role of AREG in cellular processes, particularly in cancer biology, tissue repair, and inflammation.
The primary function of AREG Gene Knockout Cell Lines is to facilitate the study of AREG's involvement in various signaling pathways, including its role as an epidermal growth factor (EGF) family member. By knocking out AREG, researchers are able to observe changes in cell proliferation, differentiation, and migration and gain insights into how AREG influences the tumor microenvironment and contributes to disease progression. This mechanistic understanding is critical in identifying novel therapeutic targets.
In both research and clinical applications, these knockout cell lines are invaluable for examining the responses of cells to different treatments, developing targeted therapies, and elucidating the molecular underpinnings of diseases where AREG is implicated. The ability to study gene function through loss-of-function mutations enhances experimental precision and provides a pathway to understand complex biological interactions.
What sets AREG Gene Knockout Cell Lines apart from other models is the thorough validation of the knockout efficiency and the preservation of the cellular context, offering a more reliable representation of in vivo conditions. This feature makes it an ideal choice for researchers who demand high fidelity in their experimental setups.
The value of AREG Gene Knockout Cell Lines to researchers and clinicians cannot be overstated; they represent a powerful tool for dissecting the biology of AREG and its involvement in various pathological conditions. By providing a clear understanding of gene function, these cell lines pave the way for advances in therapeutic strategies.
With a strong commitment to scientific innovation and excellence, our company specializes in delivering high-quality biological products tailored to meet the evolving needs of the research community, enabling breakthroughs in understanding complex biological systems.
Please note that all services are for research use only. Not intended for any clinical use.
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