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AQP3 Knockout Cell Lines

Gene: AQP3

Official Full Name: aquaporin 3 (Gill blood group)provided by HGNC

Gene Summary: This gene encodes the water channel protein aquaporin 3. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein, also known as aquaporin 0. Aquaporin 3 is localized at the basal lateral membranes of collecting duct cells in the kidney. In addition to its water channel function, aquaporin 3 has been found to facilitate the transport of nonionic small solutes such as urea and glycerol, but to a smaller degree. It has been suggested that water channels can be functionally heterogeneous and possess water and solute permeation mechanisms. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO05230 AQP3 Knockout cell line (HeLa) Human AQP3 1:3~1:6 Negative Online Inquiry
KO05231 AQP3 Knockout cell line (HCT 116) Human AQP3 1:2~1:4 Negative Online Inquiry
KO05232 AQP3 Knockout cell line (HEK293) Human AQP3 1:3~1:6 Negative Online Inquiry
KO05233 AQP3 Knockout cell line (A549) Human AQP3 1:3~1:4 Negative Online Inquiry

Background

AQP3 Gene Knockout Cell Lines are specialized cell lines in which the aquaporin-3 (AQP3) gene has been purposefully disrupted or "knocked out," providing crucial tools for studying the physiological roles of this water channel protein. AQP3 is integral to the transport of water and glycerol across cellular membranes, impacting various biological processes such as osmoregulation, cell proliferation, and apoptosis.

The key function of these knockout cell lines lies in their ability to allow researchers to dissect the specific roles of AQP3 in health and disease. By eliminating AQP3 expression, these cell lines facilitate the study of its contributions to cellular function and the underlying mechanisms related to hydration, metabolic regulation, and tissue homeostasis. The use of knockout technology provides enhanced clarity in experimental designs, allowing researchers to assess the consequences of AQP3 absence on cellular activities, signaling pathways, and responses to environmental changes.

From a scientific standpoint, AQP3 Gene Knockout Cell Lines are invaluable in various research applications, including but not limited to, cancer biology, skin physiology, and diabetes research. Investigating the role of AQP3 can open avenues for novel therapeutic strategies targeting fluid balance disorders and promote a deeper understanding of its contributions to tumor microenvironments.

Compared to alternative models, such as wild-type cell lines, these knockout lines offer specificity and precision, allowing for more accurate interpretations of results. The absence of the gene removes confounding factors that can obscure data, which is especially crucial in high-stakes research contexts.

For researchers and clinicians, AQP3 Gene Knockout Cell Lines provide a robust platform for influential discoveries while addressing critical questions in cellular biology. Their application in high-throughput screening and therapeutic development underlines their importance in advancing biomedical research.

Our company specializes in the production of genetically modified cell lines, boasting a commitment to precision and quality in all our biological products. With years of expertise in the field, we ensure that our AQP3 Gene Knockout Cell Lines meet rigorous scientific standards to support your research initiatives effectively.

Please note that all services are for research use only. Not intended for any clinical use.

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