Gene: APPL2
Official Full Name: adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2provided by HGNC
Gene Summary: The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5, which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain, a central pleckstrin homology (PH) domain, and a C-terminal phosphotyrosine binding (PTB) domain, and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome, also known as Phelan-McDermid syndrome. [provided by RefSeq, Oct 2011]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19754 | APPL2 Knockout cell line (HeLa) | Human | APPL2 | 1:3~1:6 | Negative | Online Inquiry |
KO19755 | APPL2 Knockout cell line (HCT 116) | Human | APPL2 | 1:2~1:4 | Negative | Online Inquiry |
KO19756 | APPL2 Knockout cell line (HEK293) | Human | APPL2 | 1:3~1:6 | Negative | Online Inquiry |
KO19757 | APPL2 Knockout cell line (A549) | Human | APPL2 | 1:3~1:4 | Negative | Online Inquiry |
APPL2 Gene Knockout Cell Lines are specialized human cell lines in which the APPL2 gene has been systematically removed to facilitate the study of its role in cellular processes. The APPL2 gene encodes a protein that is implicated in intracellular trafficking and signaling, particularly in relation to endosomal function and gene expression regulation. Through targeted gene editing techniques, such as CRISPR-Cas9, these knockout cell lines enable researchers to dissect the specific functions of APPL2, examine its impact on cellular metabolism, and explore its potential involvement in various diseases.
The primary mechanism by which APPL2 influences cellular behavior involves its interaction with several key signaling pathways that relate to development, metabolic homeostasis, and apoptosis. By utilizing the APPL2 Gene Knockout Cell Lines, researchers can effectively elucidate how the absence of this gene alters normal cell function, leading to a deeper understanding of its biological significance.
The scientific importance of APPL2 Gene Knockout Cell Lines lies in their relevance to biomedical research, particularly in studying conditions such as cancer, obesity, and neurodegenerative diseases. In a clinical setting, these cell lines can serve as valuable tools for drug discovery and testing, allowing for the identification of novel therapeutic targets and the development of personalized medicine strategies.
A unique advantage of our APPL2 Gene Knockout Cell Lines is the high specificity and reliability of the knockout achieved. Compared to other gene-editing products, our cell lines are validated through rigorous testing to ensure that they exhibit consistent gene disruption and maintain their physiological characteristics, making them an ideal choice for experimental reproducibility.
For researchers and clinicians, the ability to work with these specialized cell lines facilitates groundbreaking discoveries and enhances their understanding of critical biological processes. Investing in APPL2 Gene Knockout Cell Lines not only bridges the gap between basic research and clinical applications but also empowers scientists to explore new frontiers in genetic and molecular research.
Our company is dedicated to providing high-quality biological products, leveraging advanced gene-editing technologies and extensive expertise to support researchers in their quest to reveal the complexities of life at the cellular level. With our APPL2 Gene Knockout Cell Lines, we offer a proven solution that enhances research capabilities and fosters innovation in the life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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