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APOBEC3H Knockout Cell Lines

Gene: APOBEC3H

Official Full Name: apolipoprotein B mRNA editing enzyme catalytic subunit 3Hprovided by HGNC

Gene Summary: This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO20334 APOBEC3H Knockout cell line (HCT 116) Human APOBEC3H 1:2~1:4 Negative Online Inquiry

Background

APOBEC3H Gene Knockout Cell Lines are specialized cellular models that have been engineered to specifically lack the APOBEC3H gene, a member of the APOBEC family of proteins known for their role in innate immunity and regulation of retroviral infections. By targeting this gene for deletion, these cell lines provide researchers with a powerful tool to study the functions of APOBEC3H in a controlled experimental environment.

The key functions of these knockout cell lines revolve around their ability to facilitate investigations into the mechanisms by which the APOBEC3H protein influences viral replication, particularly in the context of HIV and other retroviruses. By observing cellular responses in the absence of this critical gene, scientists can gain insight into the interactions between viral pathogens and host defense mechanisms, elucidating the broader implications for viral pathogenesis and therapeutic strategies.

The scientific importance of APOBEC3H Gene Knockout Cell Lines is underscored by their applications in both basic and translational research settings. They serve as a model for studying viral resistance, developing antiviral drugs, and uncovering novel therapeutic interventions for infectious diseases. Furthermore, due to variations in the APOBEC3H gene among different populations, these cell lines can also aid in pharmacogenomics and personalized medicine studies.

What sets these cell lines apart from alternative models is their specific deletion of the APOBEC3H gene, allowing researchers to avoid the confounding effects often encountered with partial inactivation or overexpression systems. This precision enables more accurate assessments of gene function and facilitates reproducibility in experimental results, thereby enhancing the integrity of scientific investigations.

For researchers and clinicians focused on viral research, these innovative cell lines offer unparalleled value. They empower users to dissect complex biological questions, improve their understanding of host-pathogen interactions, and ultimately contribute to advancements in therapeutic designs.

Our company specializes in providing high-quality, genetically modified cell lines that meet rigorous scientific standards, supporting the diverse needs of the research community. With our commitment to excellence, we ensure that our products remain at the forefront of scientific innovation, enabling breakthroughs in biological research and clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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