Gene: APLF
Official Full Name: aprataxin and PNKP like factorprovided by HGNC
Gene Summary: Enables several functions, including ADP-D-ribose modification-dependent protein binding activity; nuclease activity; and poly-ADP-D-ribose binding activity. Involved in DNA repair; DNA repair-dependent chromatin remodeling; and protein localization to chromatin. Acts upstream of or within positive regulation of DNA ligation. Located in nucleoplasm. Is active in site of double-strand break. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38005 | APLF Knockout cell line (A549) | Human | APLF | 1:3~1:4 | Negative | Online Inquiry |
APLF Gene Knockout Cell Lines are expertly engineered cellular models designed to facilitate the exploration of gene function and the elucidation of disease mechanisms. Utilizing advanced CRISPR/Cas9 technology, these cell lines precisely disrupt specific genes, enabling researchers to identify the roles that various genes play in biological processes and pathological conditions. By significantly simplifying the generation of knockout models, APLF Gene Knockout Cell Lines empower scientists to conduct functional studies with unparalleled efficiency and accuracy.
The key mechanism driving the utility of APLF Gene Knockout Cell Lines is the inherent specificity of the CRISPR/Cas9 system. This approach targets DNA sequences, creating double-strand breaks that, when repaired by the cell, can lead to insertion or deletion mutations—effectively knocking out the gene of interest. This allows for comprehensive studies on gene function, gene expression regulation, and the interactions between genetic and environmental variables, with a broad impact on cancer research, neurobiology, and pharmacogenomics.
In clinical and research settings, these knockout cell lines are invaluable for drug discovery, biomarker validation, and the development of gene therapies. They provide researchers with the ability to mimic disease states, which is crucial for testing the efficacy of new therapeutics. Compared to traditional gene knockout methods, such as homologous recombination, APLF Gene Knockout Cell Lines deliver faster results, greater precision, and higher throughput, thus significantly enhancing the research timeline and outcomes.
Furthermore, APLF Gene Knockout Cell Lines offer the unique advantage of being pre-validated for functionality, ensuring that researchers can focus on their experiments without the uncertainties typical of other knockout approaches. This reliability translates into robust data generation and increases the reproducibility of experimental results, making APLF’s offering a trusted choice for both academic and industrial laboratories.
By choosing APLF Gene Knockout Cell Lines, users gain access to advanced tools backed by our extensive expertise in genetic engineering and cell biology. Our commitment to quality and innovation positions us as a leader in the field of biological products, dedicated to driving impactful discoveries in life sciences.
Please note that all services are for research use only. Not intended for any clinical use.
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