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API5 Knockout Cell Lines

Gene: API5

Official Full Name: apoptosis inhibitor 5provided by HGNC

Gene Summary: This gene encodes an apoptosis inhibitory protein whose expression prevents apoptosis after growth factor deprivation. This protein suppresses the transcription factor E2F1-induced apoptosis and also interacts with, and negatively regulates Acinus, a nuclear factor involved in apoptotic DNA fragmentation. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34081 API5 Knockout cell line (HeLa) Human API5 1:3~1:6 Negative Online Inquiry
KO34082 API5 Knockout cell line (HCT 116) Human API5 1:2~1:4 Negative Online Inquiry
KO34083 API5 Knockout cell line (HEK293) Human API5 1:3~1:6 Negative Online Inquiry
KO34084 API5 Knockout cell line (A549) Human API5 1:3~1:4 Negative Online Inquiry

Background

API5 Gene Knockout Cell Lines are a cutting-edge tool designed for researchers investigating the role of the API5 gene in cellular processes, such as apoptosis, proliferation, and tumorigenesis. These engineered cell lines are generated through CRISPR-Cas9 technology to create precise knockout models, enabling scientists to explore the functional consequences of API5 gene disruption in various biological contexts.

The primary function of API5 Gene Knockout Cell Lines is to facilitate the study of gene-related mechanisms by allowing researchers to observe how the absence of the API5 protein impacts cell behavior and signaling pathways. The API5 gene is known to be involved in the regulation of apoptosis and has been implicated in cancer cell survival, making these knockout lines invaluable for dissecting cancer biology, drug response, and therapeutic resistance phenomena. Researchers can utilize these models to elucidate the gene's role within oncogenic signaling networks, as well as its interactions with other cellular molecules and pathways.

The scientific importance of API5 Gene Knockout Cell Lines is underscored by their applicability in both research and clinical settings. In the laboratory, they serve as a fundamental resource for basic science, enabling advancements in gene therapy approaches, cancer treatment strategies, and the development of targeted therapies. In clinical research, these cell lines can help in identifying biomarkers for patient stratification and in testing pharmacological agents that target tumor cells selectively.

One of the critical advantages of our API5 Gene Knockout Cell Lines is their reproducible and validated knockout efficiency, which ensures consistency in experimental outcomes. Compared to alternative models, our products are rigorously characterized for genetic integrity and functional validity, providing researchers with confidence that they are working with authentic gene-disrupted lines. Additionally, the ease of use in experimental setups, combined with comprehensive technical support, streamlines research processes and boosts productivity.

For researchers, clinicians, and biotechnologists, API5 Gene Knockout Cell Lines represent an essential resource for advancing knowledge in molecular biology and improving therapeutic outcomes. They embody a unique opportunity to bridge laboratory discoveries with clinical innovations, ultimately contributing to better patient care.

At our company, we pride ourselves on our commitment to high-quality biological products and a dedication to supporting scientific advancements. Our expertise in the development of gene manipulation tools positions us at the forefront of biotechnological innovations, ensuring that our clients receive unparalleled products for their research needs.

Please note that all services are for research use only. Not intended for any clinical use.

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