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APBA2 Knockout Cell Lines

Gene: APBA2

Official Full Name: amyloid beta precursor protein binding family A member 2provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the X11 protein family. It is a neuronal adapter protein that interacts with the Alzheimer's disease amyloid precursor protein (APP). It stabilizes APP and inhibits production of proteolytic APP fragments including the A beta peptide that is deposited in the brains of Alzheimer's disease patients. This gene product is believed to be involved in signal transduction processes. It is also regarded as a putative vesicular trafficking protein in the brain that can form a complex with the potential to couple synaptic vesicle exocytosis to neuronal cell adhesion. [provided by RefSeq, Jul 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38984 APBA2 Knockout cell line (HEK293) Human APBA2 1:3~1:6 Negative Online Inquiry
KO38985 APBA2 Knockout cell line (A549) Human APBA2 1:3~1:4 Negative Online Inquiry

Background

APBA2 Gene Knockout Cell Lines are genetically modified cells in which the APBA2 gene has been deactivated, allowing researchers to study the gene's function and related cellular processes in detail. This innovative product is designed to facilitate the investigation of APBA2's role in various biological pathways, particularly those involved in synaptic function and neuromodulation, which have been implicated in neurodegenerative diseases and psychiatric disorders.

The primary function of these cell lines is to provide a clean genetic background for functional assays, where the absence of the APBA2 protein allows for the observation of phenotypic changes and cellular behaviors that occur upon its knockout. Advanced CRISPR-Cas9 technology was employed to ensure precise and efficient gene editing, resulting in stable cell lines that exhibit consistent knockout characteristics. By utilizing these cell lines, researchers can gain insights into the molecular mechanisms by which APBA2 contributes to synaptic integrity and neuronal signaling.

Scientifically, these cell lines are invaluable for both basic research and translational studies. They serve as powerful tools for examining the role of APBA2 in health and disease, and they can be used in drug discovery processes to identify potential therapeutic targets. Moreover, they offer a robust platform for testing the efficacy of compounds aimed at modulating APBA2-related pathways, thereby accelerating the development of novel therapies.

The APBA2 Gene Knockout Cell Lines distinguish themselves from other products on the market through their reliability, ease of use, and comprehensive support offered to researchers. Unlike transient knockdown methods, these stable knockout lines provide long-term solutions for experimental reproducibility and thorough study of gene function over extended periods. Additionally, the validation of these lines by extensive characterization adds to their credibility as a reliable resource for ongoing investigations.

For researchers and clinicians aiming to unravel the complexities of neurobiology and related disorders, the APBA2 Gene Knockout Cell Lines represent an essential asset that bridges the gap between fundamental research and clinical application. Our company specializes in developing high-quality biological products, supported by a team of experts dedicated to advancing scientific understanding and innovation in the field. With our commitment to excellence and reliable customer support, we empower researchers to achieve impactful outcomes in their studies.

Please note that all services are for research use only. Not intended for any clinical use.

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