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AP3M1 Knockout Cell Lines

Gene: AP3M1

Official Full Name: adaptor related protein complex 3 subunit mu 1provided by HGNC

Gene Summary: The protein encoded by this gene is the medium subunit of AP-3, which is an adaptor-related protein complex associated with the Golgi region as well as more peripheral intracellular structures. AP-3 facilitates the budding of vesicles from the Golgi membrane, and it may directly function in protein sorting to the endosomal/lysosomal system. AP-3 is a heterotetrameric protein complex composed of two large subunits (delta and beta3), a medium subunit (mu3), and a small subunit (sigma 3). Mutations in one of the large subunits of AP-3 have been associated with the Hermansky-Pudlak syndrome, a genetic disorder characterized by defective lysosome-related organelles. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Feb 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00436 AP3M1 knockout cell line (HeLa) Human AP3M1 1:3~1:6 Negative Online Inquiry
KO27936 AP3M1 Knockout cell line (HCT 116) Human AP3M1 1:2~1:4 Negative Online Inquiry
KO27937 AP3M1 Knockout cell line (HEK293) Human AP3M1 1:3~1:6 Negative Online Inquiry
KO27938 AP3M1 Knockout cell line (A549) Human AP3M1 1:3~1:4 Negative Online Inquiry

Background

AP3M1 Gene Knockout Cell Lines are a sophisticated biological tool designed for advanced research in cellular and molecular biology. These cell lines are genetically engineered to lack the AP3M1 gene, which encodes a crucial component of the adaptor protein complex 3 (AP-3), involved in endosomal trafficking and cellular communication. By creating a loss-of-function model, researchers can investigate the specific roles and implications of AP3M1 in various biological processes, including protein sorting, membrane biogenesis, and synaptic function.

The mechanism behind the function of AP3M1 Gene Knockout Cell Lines revolves around the disruption of normal endosomal trafficking pathways that can lead to altered cellular signaling and response, making them invaluable for studies on neurodegenerative diseases, cancer, and other conditions where cellular communication is disrupted. These cell lines provide a controlled environment for studying the effects of AP3M1 loss on cellular morphology, behavior, and gene expression, enabling researchers to draw meaningful conclusions about its role in health and disease.

The scientific importance of these cell lines extends into therapeutic research, providing a platform for drug screening and the development of targeted therapies that may exploit the pathways affected by AP3M1 dysfunction. Unlike conventional methods that may produce inconsistent results, the stable gene knockout cell lines ensure reproducibility and reliability in experimental outcomes, making them a preferred choice for time-sensitive research.

The specific advantages of AP3M1 Gene Knockout Cell Lines include their ease of use in a variety of assays, including high-throughput screening, and their compatibility with standard cell culture practices. Furthermore, the precise knockout at a genomic level minimizes off-target effects commonly encountered in CRISPR or RNAi approaches, providing greater confidence in experimental interpretations.

For researchers and clinicians, the value of integrating AP3M1 Gene Knockout Cell Lines into their investigation lies in the potential to uncover novel therapeutic targets and elucidate the underlying mechanisms of disease. These cell lines enable a deeper understanding of cellular pathways and foster the development of innovative treatments that can significantly impact patient care.

With a commitment to excellence in biological products, our company has established itself as a leader in providing cutting-edge research tools. We are dedicated to advancing scientific knowledge and supporting the community with high-quality, reliable cell lines that empower groundbreaking research.

Please note that all services are for research use only. Not intended for any clinical use.

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