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AP3B2 Knockout Cell Lines

Gene: AP3B2

Official Full Name: adaptor related protein complex 3 subunit beta 2provided by HGNC

Gene Summary: Adaptor protein complex 3 (AP-3 complex) is a heterotrimeric protein complex involved in the formation of clathrin-coated synaptic vesicles. The protein encoded by this gene represents the beta subunit of the neuron-specific AP-3 complex and was first identified as the target antigen in human paraneoplastic neurologic disorders. The encoded subunit binds clathrin and is phosphorylated by a casein kinase-like protein, which mediates synaptic vesicle coat assembly. Defects in this gene are a cause of early-onset epileptic encephalopathy. [provided by RefSeq, Feb 2017]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34312 AP3B2 Knockout cell line (HEK293) Human AP3B2 1:3~1:6 Negative Online Inquiry

Background

AP3B2 Gene Knockout Cell Lines are meticulously engineered cellular models that harbor targeted deletions of the AP3B2 gene, a critical component of the adaptin protein complex involved in intracellular trafficking. These cell lines serve as an invaluable tool for researchers investigating the functional roles of the AP3B2 gene in various cellular processes, including endocytosis and exocytosis, as well as protein sorting and transport. By using CRISPR-Cas9 gene editing technology, we create precise and stable knockout models, ensuring that the mutation is heritable and fully characterizes the biological implications of the AP3B2 gene.

In terms of functionality, these cell lines provide researchers with a unique opportunity to observe phenotypic changes associated with the loss of AP3B2 expression. This can lead to insights into cellular mechanisms underlying various diseases, particularly those related to neurotransmitter regulation and neurodegenerative disorders. Furthermore, the availability of these knockout models enhances the validation of potential therapeutic targets and fosters innovation in drug discovery.

The scientific importance of AP3B2 Gene Knockout Cell Lines spans both basic research and clinical applications. They are crucial for understanding the etiology of diseases like Schizophrenia and other mental health disorders linked to cellular transport defects. Unlike traditional gene silencing techniques that may yield variable results, these knockout cell lines provide a complete lack of gene expression, yielding clearer and more reproducible data.

One of the standout advantages of our AP3B2 Gene Knockout Cell Lines is the high degree of specificity and reliability they offer researchers. By eliminating the AP3B2 gene completely, you are assured of robust genetic backgrounds that reduce confounding variables in experimental outcomes. This assures users that their findings will contribute meaningful data to the scientific community, enhancing the overall quality of both experimental and clinical research.

Investing in AP3B2 Gene Knockout Cell Lines means gaining access to a product born from meticulous science and expertise in cell line development. Our company prides itself on delivering rigorously validated cellular models that not only meet, but exceed industry standards. By choosing our products, researchers and clinicians gain pioneering tools that can significantly accelerate their investigations, foster groundbreaking therapeutic discoveries, and ultimately improve patient outcomes.

Please note that all services are for research use only. Not intended for any clinical use.

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