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AP3B1 Knockout Cell Lines

Gene: AP3B1

Official Full Name: adaptor related protein complex 3 subunit beta 1provided by HGNC

Gene Summary: This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34043 AP3B1 Knockout cell line (HeLa) Human AP3B1 1:3~1:6 Negative Online Inquiry
KO34044 AP3B1 Knockout cell line (HCT 116) Human AP3B1 1:2~1:4 Negative Online Inquiry
KO34045 AP3B1 Knockout cell line (HEK293) Human AP3B1 1:3~1:6 Negative Online Inquiry
KO34046 AP3B1 Knockout cell line (A549) Human AP3B1 1:3~1:4 Negative Online Inquiry

Background

AP3B1 Gene Knockout Cell Lines represent a cutting-edge resource in molecular biology, specifically designed to enable researchers to study the function and role of the AP3B1 gene, which encodes the β3A subunit of the adapter protein complex 3 (AP-3). These cell lines are meticulously engineered to disrupt the expression of the AP3B1 gene, providing a unique system to investigate the implications of apical sorting and vesicle trafficking in both normal physiological processes and disease states.

The key function of the AP3B1 knockout cell lines lies in their ability to facilitate the exploration of intracellular transport mechanisms. By generating a precise genetic alteration, these cell lines allow researchers to dissect the cellular pathways involving the AP-3 complex, enhancing the understanding of how mutations can lead to various disorders, including neurological and immune-related conditions. When utilized in experimental setups, these knockout lines can elucidate the impact of AP3B1 deficiency on protein sorting, signal transduction, and cell survival.

From a scientific perspective, AP3B1 Gene Knockout Cell Lines are invaluable tools for basic research and translational studies. Their applications span understanding disease mechanisms to screening therapeutic targets, making them essential for both academic and clinical research environments.

Compared to alternative methods such as traditional RNA interference, which often leads to incomplete gene silencing, the knockout strategy provides a more robust and stable system for studying gene function. This reflects a deeper and more permanent alteration, allowing for clearer interpretations of the gene's role in cellular contexts.

The value of AP3B1 Gene Knockout Cell Lines extends beyond research utility; they also present an opportunity to drive innovation in therapeutic development. For researchers and clinicians alike, these tools offer not only a chance to unravel complex biological systems but also to potentially identify novel intervention pathways.

Our company prides itself on expertise in producing high-quality, rigorously validated biological products, ensuring that our offerings, like the AP3B1 Gene Knockout Cell Lines, meet the highest standards of reliability and effectiveness in scientific research.

Please note that all services are for research use only. Not intended for any clinical use.

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