Gene: AP2B1
Official Full Name: adaptor related protein complex 2 subunit beta 1provided by HGNC
Gene Summary: The protein encoded by this gene is one of two large chain components of the assembly protein complex 2, which serves to link clathrin to receptors in coated vesicles. The encoded protein is found on the cytoplasmic face of coated vesicles in the plasma membrane. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO39084 | AP2B1 Knockout cell line (HeLa) | Human | AP2B1 | 1:3~1:6 | Negative | Online Inquiry |
KO39085 | AP2B1 Knockout cell line (HCT 116) | Human | AP2B1 | 1:2~1:4 | Negative | Online Inquiry |
KO39086 | AP2B1 Knockout cell line (HEK293) | Human | AP2B1 | 1:3~1:6 | Negative | Online Inquiry |
KO39087 | AP2B1 Knockout cell line (A549) | Human | AP2B1 | 1:3~1:4 | Negative | Online Inquiry |
AP2B1 Gene Knockout Cell Lines are specially engineered cellular models in which the AP2B1 gene has been inactivated to elucidate its function and to study the implications of its loss in various biological processes. The AP2B1 gene encodes a protein that is part of the clathrin-adaptor protein complex, playing a crucial role in clathrin-mediated endocytosis, a critical mechanism for cellular uptake of nutrients, receptors, and signaling molecules.
By removing the AP2B1 gene, these knockout cell lines facilitate the investigation of downstream signaling pathways and molecular interactions altered by the absence of this gene. Researchers can utilize these cell lines to analyze changes in endocytosis, cellular uptake mechanisms, and their associated effects on cell signaling and metabolism. This precision allows for a deeper understanding of various diseases, including cancer and neurological disorders, where dysregulation of endocytosis may play a pivotal role.
The scientific importance of AP2B1 Gene Knockout Cell Lines is underscored by their applications in both basic research and clinical settings. These cell lines are invaluable for drug discovery and development, enabling researchers to screen potential therapeutic compounds that target pathways affected by the loss of AP2B1. Furthermore, they serve as a model system for investigating gene function and the molecular basis of disease, which is critical for advancing personalized medicine.
Unlike traditional cell lines, these knockout models provide a more accurate representation of physiological conditions, reducing artifacts associated with overexpressed or wild-type genes. The ability to study the direct effects of gene inactivation positions AP2B1 Gene Knockout Cell Lines as a unique and invaluable tool for researchers aiming to dissect complex biological systems.
Choosing AP2B1 Gene Knockout Cell Lines signifies a commitment to advancing scientific knowledge. Our company specializes in producing high-quality, rigorously validated biological products, supported by in-depth expertise in genetic engineering and cellular biology. This commitment not only enhances the reliability of your results but also empowers your research endeavors, ensuring you stay at the forefront of discovery.
Please note that all services are for research use only. Not intended for any clinical use.
If your question is not addressed through these resources, you can fill out the online form below and we will answer your question as soon as possible.
There is no product in your cart. |
CD Biosynsis is a leading customer-focused biotechnology company dedicated to providing high-quality products, comprehensive service packages, and tailored solutions to support and facilitate the applications of synthetic biology in a wide range of areas.