Gene: AOC2
Official Full Name: amine oxidase copper containing 2provided by HGNC
Gene Summary: Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38990 | AOC2 Knockout cell line (HCT 116) | Human | AOC2 | 1:2~1:4 | Negative | Online Inquiry |
KO38991 | AOC2 Knockout cell line (HEK293) | Human | AOC2 | 1:3~1:6 | Negative | Online Inquiry |
KO38992 | AOC2 Knockout cell line (A549) | Human | AOC2 | 1:3~1:4 | Negative | Online Inquiry |
AOC2 Gene Knockout Cell Lines are specialized cell lines engineered to lack the expression of the amine oxidase, copper-containing 2 (AOC2) gene. This gene is primarily involved in the oxidative deamination of monoamines, playing a critical role in cellular metabolism and neurotransmitter regulation. By utilizing these knockout lines, researchers can study the biological consequences associated with the absence of AOC2, including effects on cell proliferation, metabolic pathways, and neurotransmitter dynamics.
The primary mechanism underlying the utility of AOC2 Gene Knockout Cell Lines lies in their ability to serve as a robust model for investigating the cellular and molecular implications of AOC2 deficiency. This knockout approach enables in-depth studies into how the loss of this gene affects various physiological processes, particularly in the context of neurobiology and cancer research. As scientists explore the implications of altered amine metabolism, these cell lines facilitate the analysis of signaling pathways and gene expression changes that may contribute to disease states.
The scientific importance of AOC2 Gene Knockout Cell Lines extends to both research and clinical applications. In research settings, they are vital for elucidating mechanisms of disease, screening for drug targets, and validating therapeutic modalities that may modulate AOC2 activity. Clinically, understanding the role of AOC2 may inform treatment strategies for neurodegenerative disorders and other conditions where monoamine regulation is disrupted.
One notable advantage of using AOC2 Gene Knockout Cell Lines is their precision. Unlike traditional methods that may involve non-specific gene disruption, these knockout lines provide a clean genetic background, ensuring any observed effects are solely due to the genetic alteration. This clarity enhances the reliability and reproducibility of experimental results, making them more attractive for peer-reviewed research.
For researchers and clinicians alike, AOC2 Gene Knockout Cell Lines offer a powerful tool to dissect the molecular underpinnings of disease and explore novel therapeutic avenues. The capacity to conduct precise, targeted studies into AOC2's role provides significant value in advancing our understanding of human health.
Our company specializes in providing high-quality biological products that support cutting-edge research. With a commitment to scientific excellence and innovation, we ensure that our products, including the AOC2 Gene Knockout Cell Lines, meet the rigorous demands of researchers in diverse fields.
Please note that all services are for research use only. Not intended for any clinical use.
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