Gene: ANXA3
Official Full Name: annexin A3provided by HGNC
Gene Summary: This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO39006 | ANXA3 Knockout cell line (HeLa) | Human | ANXA3 | 1:3~1:6 | Negative | Online Inquiry |
KO39007 | ANXA3 Knockout cell line (HCT 116) | Human | ANXA3 | 1:2~1:4 | Negative | Online Inquiry |
KO39008 | ANXA3 Knockout cell line (HEK293) | Human | ANXA3 | 1:3~1:6 | Negative | Online Inquiry |
KO39009 | ANXA3 Knockout cell line (A549) | Human | ANXA3 | 1:3~1:4 | Negative | Online Inquiry |
ANXA3 Gene Knockout Cell Lines are genetically engineered cell lines in which the ANXA3 gene has been selectively disrupted or "knocked out." This innovative product serves as a valuable tool for researchers seeking to explore the functional role of the Annexin A3 protein, which is implicated in various biological processes, including inflammation, cell signaling, and apoptosis. By eliminating the expression of the ANXA3 gene, these cell lines allow researchers to investigate the specific contributions of Annexin A3 to cellular behavior and its involvement in pathological conditions.
The key mechanism underlying these knockout cell lines involves CRISPR/Cas9 or similar gene-editing technologies that create targeted mutations, leading to a complete loss of gene function. This not only aids in dissecting the molecular pathways influenced by ANXA3 but also facilitates the study of compensatory mechanisms that may arise in the absence of this protein. Given the role of Annexin A3 in multiple diseases, including cancer and autoimmune disorders, the ability to study its function in a controlled environment enhances our understanding of these conditions and may lead to the identification of novel therapeutic targets.
The scientific importance of ANXA3 Gene Knockout Cell Lines extends to their applications in both basic research and clinical settings. They support high-throughput screening assays for drug discovery, elucidate the outcomes of genetic alterations in disease models, and serve as valuable resources in biomarker identification. Compared to traditional cell line models that retain the ANXA3 gene, these knockout lines provide unprecedented clarity in experimental results, minimizing confounding variables.
One distinct advantage of utilizing ANXA3 Gene Knockout Cell Lines is their ability to contribute to a deeper understanding of the intricate network of proteins involved in cellular communication and pathology. Researchers can expect reliable and reproducible results, ensuring the integrity of their experimental designs.
Investing in ANXA3 Gene Knockout Cell Lines not only enhances the quality of research with a focus on disease mechanisms but also aligns with the pivotal shift towards personalized medicine. This product exemplifies our commitment to delivering advanced biological solutions. Our company boasts a robust background in genetic engineering technologies, ensuring that our offerings meet the rigorous standards of the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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