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ANXA11 Knockout Cell Lines

Gene: ANXA11

Official Full Name: annexin A11provided by HGNC

Gene Summary: This gene encodes a member of the annexin family, a group of calcium-dependent phospholipid-binding proteins. Annexins have unique N-terminal domains and conserved C-terminal domains, which contain calcium-dependent phospholipid-binding sites. The encoded protein is a 56-kD antigen recognized by sera from patients with various autoimmune diseases. Several transcript variants encoding two different isoforms have been identified. [provided by RefSeq, Dec 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO38993 ANXA11 Knockout cell line (HeLa) Human ANXA11 1:3~1:6 Negative Online Inquiry
KO38994 ANXA11 Knockout cell line (HCT 116) Human ANXA11 1:2~1:4 Negative Online Inquiry
KO38995 ANXA11 Knockout cell line (HEK293) Human ANXA11 1:3~1:6 Negative Online Inquiry
KO38996 ANXA11 Knockout cell line (A549) Human ANXA11 1:3~1:4 Negative Online Inquiry

Background

ANXA11 Gene Knockout Cell Lines are genetically engineered cellular models created for the study of annexin A11 (ANXA11) functionality and its implications in various biological processes. These cell lines are modified to express a complete knockout of the ANXA11 gene, allowing researchers to observe the physiological and molecular changes that occur in the absence of this protein. ANXA11 is known to play a crucial role in cellular processes such as apoptosis, inflammatory responses, and vesicle trafficking, making it an important focus in both fundamental and translational research.

The chief mechanism of the ANXA11 Gene Knockout Cell Lines involves CRISPR-Cas9 technology, which facilitates precise modifications in the target gene. Through this innovative approach, scientists can produce high-efficiency knockouts with minimal off-target effects, ensuring that the results are scientifically valid and reproducible. Researchers utilizing these cell lines can investigate ANXA11's role in various disease models, including autoimmunity and cancer, providing insights into its function and potential as a therapeutic target.

The scientific importance of these knockout cell lines is underscored by their versatility in research and clinical applications. They serve as invaluable tools for elucidating the molecular mechanisms underlying diseases associated with ANXA11 dysregulation. Furthermore, these models can aid in drug discovery efforts, providing a platform to evaluate the efficacy and safety of new compounds targeting pathways influenced by annexin A11.

What sets our ANXA11 Gene Knockout Cell Lines apart from alternatives is the rigor of our validation processes, ensuring superior quality and reliability. Each cell line is extensively characterized for gene editing success, expression profiling, and functional assays, providing researchers with confidence in their experimental designs. Additionally, our commitment to customer support and ongoing collaboration enhances the user experience, offering troubleshooting and insights from our expert team.

For researchers and clinicians focused on advancing the understanding of cellular behavior and therapeutic approaches, ANXA11 Gene Knockout Cell Lines represent a critical asset. By choosing our product, users gain access to a scientifically validated resource backed by our expertise in cutting-edge genetic engineering techniques, ensuring they are equipped to propel their research initiatives forward.

Please note that all services are for research use only. Not intended for any clinical use.

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