Gene: ANO8
Official Full Name: anoctamin 8provided by HGNC
Gene Summary: Enables intracellularly calcium-gated chloride channel activity. Involved in chloride transmembrane transport. Located in plasma membrane. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19797 | ANO8 Knockout cell line (HeLa) | Human | ANO8 | 1:3~1:6 | Negative | Online Inquiry |
KO19798 | ANO8 Knockout cell line (HCT 116) | Human | ANO8 | 1:2~1:4 | Negative | Online Inquiry |
KO19799 | ANO8 Knockout cell line (HEK293) | Human | ANO8 | 1:3~1:6 | Negative | Online Inquiry |
KO19800 | ANO8 Knockout cell line (A549) | Human | ANO8 | 1:3~1:4 | Negative | Online Inquiry |
ANO8 Gene Knockout Cell Lines are specially engineered cellular models designed to silence the expression of the ANO8 gene, which encodes for the anoctamin 8 protein. This innovative product serves as a crucial tool for researchers aiming to elucidate the role of ANO8 in various biological processes and diseases. By creating specific knockout cell lines, researchers can examine the physiological and pathological consequences of the absence of ANO8, leading to greater insights into its functional significance in cellular signaling pathways and membrane dynamics.
The mechanism of action relies on precise genetic modification techniques, such as CRISPR-Cas9 or homologous recombination, to create frameshift mutations in the ANO8 gene. This targeted approach allows for a thorough investigation of the gene's contributions to ion transport, cellular motility, and potential roles in oncogenesis. The use of knockout cell lines enhances the reproducibility and specificity of experimental outcomes, making them indispensable in functional genomics and drug discovery applications.
The scientific importance of ANO8 Gene Knockout Cell Lines extends into both research and clinical realms. Studies involving these models can yield valuable data regarding the regulation of ion channels, paving the way for novel therapeutic strategies in conditions like cancer and neurodegenerative disorders. Furthermore, these cell lines are invaluable in pharmacological assays, providing a robust system for screening compounds that may modulate ANO8 function.
What sets ANO8 Gene Knockout Cell Lines apart from conventional cellular models is their high specificity and ease of use. Unlike non-targeted approaches, these knockout lines offer unprecedented clarity in outlining cellular responses purely attributable to the loss of ANO8 activity. This attribute provides researchers with a more accurate platform to explore gene function without confounding factors.
For researchers and clinicians alike, the value of ANO8 Gene Knockout Cell Lines is evident in their ability to facilitate breakthroughs in understanding gene function, advancing therapeutic development, and driving innovation in biomedical research. Our company brings extensive expertise in cell line development, ensuring the highest quality and reliability in our products, and our commitment to supporting the scientific community guarantees that our offerings will continue to meet the evolving needs of researchers and healthcare professionals.
Please note that all services are for research use only. Not intended for any clinical use.
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