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ANO5 Knockout Cell Lines

Gene: ANO5

Official Full Name: anoctamin 5provided by HGNC

Gene Summary: This gene encodes a member of the anoctamin family of transmembrane proteins. The encoded protein is likely a calcium activated chloride channel. Mutations in this gene have been associated with gnathodiaphyseal dysplasia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2009]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO35593 ANO5 Knockout cell line (HCT 116) Human ANO5 1:2~1:4 Negative Online Inquiry
KO35594 ANO5 Knockout cell line (HEK293) Human ANO5 1:3~1:6 Negative Online Inquiry
KO35595 ANO5 Knockout cell line (A549) Human ANO5 1:3~1:4 Negative Online Inquiry

Background

ANO5 Gene Knockout Cell Lines represent a cutting-edge biological tool designed for the investigation of the ANO5 gene's function and its implications in various physiological and pathological conditions. These specially engineered cell lines lack functional copies of the ANO5 gene, allowing researchers to dissect the molecular mechanisms underlying its role in cellular processes such as ion transport, muscle function, and potential disease pathways, including specific muscular dystrophies.

The ANO5 gene encodes a member of the anoctamin family of proteins, which function as calcium-activated chloride channels. By knocking out this gene, the provided cell lines facilitate the study of alterations in ion conductance and osmotic balance, enhancing understanding of cellular excitability and muscle contractility. Furthermore, these cell lines serve as valuable models to explore therapeutic strategies, as researchers can assess gene editing technologies or pharmacological interventions aimed at restoring normal cellular function.

The scientific importance of ANO5 Gene Knockout Cell Lines is underscored by their applicability in both basic research and translational studies. Researchers can utilize these models to investigate the pathogenesis of diseases linked to the ANO5 gene, opening avenues for the development of targeted therapies. The generation of these cell lines also addresses a significant gap in existing models; few alternatives provide such precise gene-targeting capabilities to elucidate the function of less understood genes.

In comparison to traditional wild-type models or less specific gene editing methods, ANO5 Gene Knockout Cell Lines offer superior specificity and reproducibility, minimizing variability and enhancing the robustness of experimental outcomes. Their utilization can lead to faster, more reliable insights, ultimately accelerating the pace of discovery in the realms of genetics and cell biology.

In summary, these specialized cell lines represent an invaluable asset for researchers and clinicians focusing on muscle pathologies and ion channel functionality. Our company brings extensive expertise in the development of high-quality biological models, ensuring that you have the most reliable tools at your disposal to advance your research objectives.

Please note that all services are for research use only. Not intended for any clinical use.

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