Gene: ANLN
Official Full Name: anillin, actin binding proteinprovided by HGNC
Gene Summary: This gene encodes an actin-binding protein that plays a role in cell growth and migration, and in cytokinesis. The encoded protein is thought to regulate actin cytoskeletal dynamics in podocytes, components of the glomerulus. Mutations in this gene are associated with focal segmental glomerulosclerosis 8. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
GP00312 | ANLN gRNA3-gRNA4 KO plasmid | ANLN | $850 | |||
KO00689 | ANLN Knockout cell line(A549) | Human | ANLN | 1:3~1:4 | Negative | Online Inquiry |
ANLN Gene Knockout Cell Lines are genetically engineered cellular models designed to study the function of the ANLN gene, which encodes for an actin-binding protein involved in processes such as cell division and migration. The creation of these knockout cell lines involves targeted gene editing technologies, such as CRISPR/Cas9, which allow for the precise deletion of the ANLN gene, resulting in a loss-of-function model. These cell lines provide invaluable insights into the biological roles that ANLN plays in various cellular processes and its implications in diseases, including cancer.
The key functions of the ANLN gene relate to its ability to regulate the actin cytoskeleton, a crucial component of cellular structure and motility. By utilizing these knockout cell lines, researchers can elucidate the molecular mechanisms by which ANLN influences cell shape, adhesion, and migration, providing a detailed understanding of its role in pathological conditions. This functional dissection is essential for uncovering the gene's contributions to tumorigenesis and metastasis, ultimately aiding in the development of targeted therapies.
In both research and clinical settings, ANLN Gene Knockout Cell Lines serve as powerful tools for drug discovery and validating therapeutic targets. They enable the identification of potential biomarkers for disease progression and treatment response, thus enhancing personalized medicine approaches. Compared to conventional cell lines, these knockout models offer a higher degree of specificity and accuracy in research outcomes due to their tightly controlled genetic alterations.
The unique selling point of ANLN Gene Knockout Cell Lines lies in their versatility and precision, allowing scientists to conduct comprehensive functional studies while minimizing off-target effects associated with less refined genetic manipulation techniques. This specificity boosts confidence in experimental results, making these cell lines an essential addition to any research laboratory focused on cytoskeletal dynamics or cancer biology.
As a leader in providing high-quality biological products, our company is committed to equipping researchers and clinicians with the tools necessary to advance scientific knowledge and improve patient outcomes. With a strong emphasis on rigorous quality control and an extensive background in genetic model development, we ensure that our ANLN Gene Knockout Cell Lines stand out as a reliable and impactful resource in the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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