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ANKRD27 Knockout Cell Lines

Gene: ANKRD27

Official Full Name: ankyrin repeat domain 27provided by HGNC

Gene Summary: Enables guanyl-nucleotide exchange factor activity and small GTPase binding activity. Involved in endocytic recycling and negative regulation of SNARE complex assembly. Acts upstream of or within early endosome to late endosome transport. Located in several cellular components, including cytosol; endosome; and lysosome. Implicated in eosinophilic esophagitis. [provided by Alliance of Genome Resources, Apr 2025]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO25212 ANKRD27 Knockout cell line (HeLa) Human ANKRD27 1:3~1:6 Negative Online Inquiry
KO25213 ANKRD27 Knockout cell line (HCT 116) Human ANKRD27 1:2~1:4 Negative Online Inquiry
KO25214 ANKRD27 Knockout cell line (HEK293) Human ANKRD27 1:3~1:6 Negative Online Inquiry
KO25215 ANKRD27 Knockout cell line (A549) Human ANKRD27 1:3~1:4 Negative Online Inquiry

Background

ANKRD27 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically designed to lack the ANKRD27 gene. This gene plays a crucial role in various cellular processes, including cell growth, differentiation, and stress response. By employing advanced CRISPR-Cas9 technology, these knockout cell lines serve as a critical tool for researchers seeking to understand the functional implications of ANKRD27 deficiency and its associated pathways.

The primary function of ANKRD27 Gene Knockout Cell Lines lies in their ability to facilitate the investigation of gene function and pathology in the absence of the ANKRD27 protein. Researchers can analyze changes in cellular behavior, such as alterations in proliferation, apoptosis, and response to pharmacological agents, providing critical insights into the gene's role in diseases such as cancer or neurodegeneration. This capability allows for targeted studies in functional genomics and systems biology that are essential in unraveling complex biological networks.

The scientific importance of these knockout cell lines extends to both research and clinical applications. They offer a robust platform for drug discovery and development, allowing for the screening of compounds that may specifically target cells lacking ANKRD27, thereby providing potential therapeutic strategies. Furthermore, they assist in validating therapeutic targets and contribute to the personalized medicine approach by revealing how specific genetic aberrations impact treatment responses.

Compared to traditional cell lines, ANKRD27 Gene Knockout Cell Lines offer several unique advantages. The precise editing achieved through CRISPR technology ensures absolute specificity and reliability, minimizing off-target effects commonly associated with previous gene-editing methods. Additionally, these knockout models can be generated in various cell types, including those relevant to human diseases, making them versatile tools for a diverse range of experimental setups.

For researchers and clinicians, investing in ANKRD27 Gene Knockout Cell Lines represents a valuable opportunity to enhance their studies with high-quality, genetically defined models. The nuanced insights gained from these cell lines are crucial for advancing our understanding of genetic diseases and developing novel therapeutic strategies.

Our company specializes in the production of advanced biological products and genetically customized cell lines, leveraging state-of-the-art technologies and rigorous quality control to ensure the highest standards. With extensive expertise in gene editing and functional genomics, we are committed to supporting the scientific community with tools that propel research forward.

Please note that all services are for research use only. Not intended for any clinical use.

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