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ALMS1 Knockout Cell Lines

Gene: ALMS1

Official Full Name: ALMS1 centrosome and basal body associated proteinprovided by HGNC

Gene Summary: This gene encodes a protein containing a large tandem-repeat domain as well as additional low complexity regions. The encoded protein functions in microtubule organization, particularly in the formation and maintanance of cilia. Mutations in this gene cause Alstrom syndrome. There is a pseudogene for this gene located adjacent in the same region of chromosome 2. Alternative splice variants have been described but their full length nature has not been determined. [provided by RefSeq, Apr 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO34434 ALMS1 Knockout cell line (HeLa) Human ALMS1 1:3~1:6 Negative Online Inquiry
KO34435 ALMS1 Knockout cell line (HCT 116) Human ALMS1 1:2~1:4 Negative Online Inquiry
KO34436 ALMS1 Knockout cell line (HEK293) Human ALMS1 1:3~1:6 Negative Online Inquiry
KO34437 ALMS1 Knockout cell line (A549) Human ALMS1 1:3~1:4 Negative Online Inquiry

Background

ALMS1 Gene Knockout Cell Lines are genetically engineered cellular models specifically designed to facilitate the study of the ALMS1 gene, which is associated with Alstrom syndrome and various reproductive and metabolic disorders. These cell lines are characterized by the complete disruption of the ALMS1 gene, allowing researchers to investigate its role in cellular processes such as cilium formation, cellular signaling, and metabolic regulation.

The key function of ALMS1 Gene Knockout Cell Lines is to provide a system for understanding the biochemical pathways that are affected by the absence of functional ALMS1. Through techniques such as CRISPR/Cas9 gene editing, these cell lines enable the observation of phenotypic changes, assessment of cellular responses, and exploration of therapeutic targets. This is crucial for elucidating the underlying mechanisms of Alstrom syndrome and for developing potential treatment strategies.

In both research and clinical settings, the scientific importance of ALMS1 Gene Knockout Cell Lines cannot be overstated. They serve as invaluable tools for drug discovery and development, contribute to the understanding of genetic diseases, and enhance the comprehension of metabolic disorders. These models provide critical insights into genotype-phenotype correlations, paving the way for personalized medicine approaches.

One of the distinguishing advantages of our ALMS1 Gene Knockout Cell Lines is their thoughtful design and validation against various criteria, ensuring that researchers receive reliable and reproducible results. Unlike alternative models, these cell lines come with comprehensive documentation and support, allowing for seamless integration into existing research workflows.

By utilizing ALMS1 Gene Knockout Cell Lines, researchers and clinicians gain access to a highly specialized tool that not only simplifies the examination of complex biological systems but also accelerates the discovery of innovative therapeutic interventions. Our company takes pride in its commitment to advancing biomedical research through high-quality products and exceptional expertise, ensuring that your studies are supported by the best resources available.

Please note that all services are for research use only. Not intended for any clinical use.

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