Gene: ALKBH8
Official Full Name: alkB homolog 8, tRNA methyltransferaseprovided by HGNC
Gene Summary: Enables tRNA (uridine) methyltransferase activity; tRNA binding activity; and zinc ion binding activity. Involved in DNA damage response; tRNA methylation; and tRNA wobble uridine modification. Located in cytosol and nucleoplasm. Implicated in autosomal recessive intellectual developmental disorder 71. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO00031 | ALKBH8 Knockout cell line (Calu-3) | Human | ALKBH8 | 1:2-1:3 | Negative | Online Inquiry |
KO23361 | ALKBH8 Knockout cell line (HeLa) | Human | ALKBH8 | 1:3~1:6 | Negative | Online Inquiry |
KO23362 | ALKBH8 Knockout cell line (HCT 116) | Human | ALKBH8 | 1:2~1:4 | Negative | Online Inquiry |
KO23363 | ALKBH8 Knockout cell line (HEK293) | Human | ALKBH8 | 1:3~1:6 | Negative | Online Inquiry |
KO23364 | ALKBH8 Knockout cell line (A549) | Human | ALKBH8 | 1:3~1:4 | Negative | Online Inquiry |
ALKBH8 Gene Knockout Cell Lines are specialized cellular systems designed to study the biological functions and pathways related to the ALKBH8 gene, which encodes a protein involved in RNA demethylation processes. This product facilitates researchers in exploring the roles of RNA modifications in cellular viability, differentiation, and response to environmental stressors.
The key function of ALKBH8 Gene Knockout Cell Lines is their ability to exhibit loss-of-function characteristics for the ALKBH8 gene, allowing for a direct investigation into the gene's contributions to RNA metabolism and gene expression regulation. By utilizing CRISPR-Cas9 technology, these knockout cell lines enable precise gene editing, facilitating the observation of phenotypic changes and molecular responses resulting from the absence of ALKBH8 function.
From a scientific perspective, ALKBH8 has been implicated in various biological contexts, including cancer research, neurobiology, and developmental studies. The understanding gained through these knockout models can lead to identifying novel therapeutic targets and potential biomarkers, thereby advancing research in both basic biology and translational medicine.
One distinct advantage of ALKBH8 Gene Knockout Cell Lines over traditional cell lines is their tailored approach to elucidate gene-specific functions through complete knockout rather than overexpression or knockdown methods, which can often exhibit artifacts or compensatory mechanisms. This specificity enhances the reliability of experimental outcomes, providing researchers and clinicians with a more accurate representation of ALKBH8's role.
Furthermore, the availability of these knockout cell lines represents a transformative resource for those engaged in detailed molecular analysis. By employing these systems, researchers can generate impactful findings that may contribute significantly to the understanding of complex biological processes and disease mechanisms.
Our company boasts extensive expertise in producing high-quality gene-modified cell lines, ensuring that each product is rigorously validated for consistency and reproducibility, thus providing researchers with the confidence they need in their experimental designs. Whether in academic or clinical realms, ALKBH8 Gene Knockout Cell Lines stand as a pivotal tool for advancing molecular biology and genetic research.
Please note that all services are for research use only. Not intended for any clinical use.
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