Gene: ALDH16A1
Official Full Name: aldehyde dehydrogenase 16 family member A1provided by HGNC
Gene Summary: This gene encodes a member of the aldehyde dehydrogenase superfamily. The family members act on aldehyde substrates and use nicotinamide adenine dinucleotide phosphate (NADP) as a cofactor. This gene is conserved in chimpanzee, dog, cow, mouse, rat, and zebrafish. The protein encoded by this gene interacts with maspardin, a protein that when truncated is responsible for Mast syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO27440 | ALDH16A1 Knockout cell line (HeLa) | Human | ALDH16A1 | 1:3~1:6 | Negative | Online Inquiry |
KO27441 | ALDH16A1 Knockout cell line (HCT 116) | Human | ALDH16A1 | 1:2~1:4 | Negative | Online Inquiry |
KO27442 | ALDH16A1 Knockout cell line (HEK293) | Human | ALDH16A1 | 1:3~1:6 | Negative | Online Inquiry |
KO27443 | ALDH16A1 Knockout cell line (A549) | Human | ALDH16A1 | 1:3~1:4 | Negative | Online Inquiry |
ALDH16A1 Gene Knockout Cell Lines are engineered human cells wherein the ALDH16A1 gene has been selectively disrupted, providing a powerful tool for researchers investigating the biological roles of this gene. Aldehyde dehydrogenases (ALDHs) are a family of enzymes integral to cellular metabolism, particularly in the metabolism of aldehydes and the protection against oxidative stress. The specific knockdown of ALDH16A1 allows for the study of its contributions to various metabolic pathways and its potential implications in conditions such as neurodegeneration and cancer.
The primary function of these knockout cell lines involves examining the changes in cellular behavior and metabolic function when Aldh16a1 expression is absent. Researchers can utilize these cell lines to elucidate the molecular mechanisms by which ALDH16A1 influences cellular responses to oxidative stress or to identify potential metabolic dysfunctions associated with the gene's loss. This platform is particularly valuable for translational research, offering insights into the enzyme’s role in various health conditions, aiding in the development of targeted therapies.
The ALDH16A1 Gene Knockout Cell Lines stand out due to their high fidelity in genetic disruption and the ease of use in downstream applications, such as drug testing and metabolic profiling, compared to alternatives like transient knockdowns that may display inconsistent results. Furthermore, the stability of the knockout ensures reliable data collection across experiments, making these cell lines a cornerstone in metabolic research.
For researchers and clinicians, investing in ALDH16A1 knockout models means deploying a robust method for studying gene function and pathology, ultimately advancing the understanding of complex diseases. Our company specializes in providing high-quality biological products, and our commitment to cutting-edge cell line development ensures that you have access to the most accurate and reliable tools for your research needs.
Please note that all services are for research use only. Not intended for any clinical use.
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