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AKT3 Knockout Cell Lines

Gene: AKT3

Official Full Name: AKT serine/threonine kinase 3provided by HGNC

Gene Summary: The protein encoded by this gene is a member of the AKT, also called PKB, serine/threonine protein kinase family. AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. This kinase has been shown to be stimulated by platelet-derived growth factor (PDGF), insulin, and insulin-like growth factor 1 (IGF1). Alternatively splice transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO11331 AKT3 Knockout cell line (HEK293) Human AKT3 1:3~1:6 Negative Online Inquiry
KO11332 AKT3 Knockout cell line (A549) Human AKT3 1:3~1:4 Negative Online Inquiry

Background

AKT3 Gene Knockout Cell Lines are engineered cellular models specifically designed to lack the expression of the AKT3 gene, a critical player in the phosphoinositide 3-kinase (PI3K) signaling pathway. This gene encodes a protein kinase involved in cellular processes such as metabolism, cell proliferation, growth, and survival. By creating these knockout cell lines, researchers can investigate the functional consequences of AKT3 deletion and its role in various diseases, particularly cancer, neurological disorders, and metabolic abnormalities.

The primary mechanism of action revolves around the absence of AKT3, which leads to the modulation of downstream signaling pathways. The disruption of these pathways allows for the study of cellular behavior in the absence of AKT3-related signaling, providing insights into cellular growth regulation and survival mechanisms. Researchers can utilize these cell lines to explore therapeutic targets, investigate disease mechanisms, and assess drug responses.

The scientific importance of AKT3 Gene Knockout Cell Lines lies in their applications across basic and translational research settings. They serve as invaluable tools for dissecting the roles of AKT3 in tumorigenesis and developing novel treatment strategies that could lead to better patient outcomes. Additionally, these cell lines can be employed to screen potential pharmaceutical compounds targeting the PI3K/AKT signaling pathway, which is notoriously implicated in the progression of various malignancies.

One unique selling point of our AKT3 Gene Knockout Cell Lines is their high fidelity and reproducibility, which are crucial for achieving consistent experimental results. Unlike competitors, we ensure that our cell lines undergo rigorous validation processes to verify complete knockout efficiency and phenotypic characterization. Moreover, our product comes with comprehensive support documents that detail optimizations for various assays that target AKT3 signaling.

For researchers and clinicians striving to enhance therapeutic interventions or uncover fundamental biological questions, our AKT3 Gene Knockout Cell Lines provide an essential resource. Their precise genetic alterations facilitate targeted studies in a controlled environment, thereby accelerating advancements in biomedical research.

At [Your Company Name], we are dedicated to delivering high-quality genetic products and have a proven track record in developing precision-engineered cell lines that meet the highest standards of scientific rigor. Our commitment to innovation empowers researchers to push the boundaries of knowledge in the life sciences.

Please note that all services are for research use only. Not intended for any clinical use.

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