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AIFM2 Knockout Cell Lines

Gene: AIFM2

Official Full Name: AIF family member 2provided by HGNC

Gene Summary: This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
GP00254 AIFM2 gRNA3-gRNA4 KO plasmid AIFM2 $850
KO00675 AIFM2 Knockout cell line(HT-1080) Human AIFM2 1:2-1:4 Negative Online Inquiry
KO06242 AIFM2 Knockout cell line (HeLa) Human AIFM2 1:3~1:6 Negative Online Inquiry
KO06243 AIFM2 Knockout cell line (HCT 116) Human AIFM2 1:2~1:4 Negative Online Inquiry
KO06244 AIFM2 Knockout cell line (HEK293) Human AIFM2 1:3~1:6 Negative Online Inquiry
KO06245 AIFM2 Knockout cell line (A549) Human AIFM2 1:3~1:4 Negative Online Inquiry

Background

AIFM2 Gene Knockout Cell Lines are specifically engineered cell lines that have undergone targeted gene disruption to knock out the function of the AIFM2 gene. This gene encodes a mitochondrial protein implicated in diverse biological processes, including apoptosis, mitochondrial dynamics, and cellular respiration. By utilizing advanced CRISPR-Cas9 gene-editing techniques, these cell lines are designed to provide a robust platform for studying the pathophysiological roles of AIFM2 and its contributions to various diseases, including neurodegenerative conditions and cancer.

The key function of AIFM2 Gene Knockout Cell Lines lies in their ability to mimic disease states by eliminating the gene of interest, allowing researchers to dissect the molecular pathways that depend on AIFM2 signaling. By observing the phenotypic and transcriptomic alterations following AIFM2 knockout, scientists can gain valuable insights into mitochondrial dysfunction and its association with cellular stress responses. This feature is particularly useful in drug discovery and understanding the efficacy of therapeutic interventions.

Scientifically, AIFM2 Gene Knockout Cell Lines are pivotal in both research and clinical settings, facilitating investigations into mitochondrial biology and the underlying mechanisms of disease. These cell lines serve as vital tools for studies aimed at identifying novel therapeutic targets and developing interventions to counteract mitochondrial-related diseases.

Unique advantages of these knockout cell lines include high specificity and reproducibility in experiments, enabling more reliable experimental outcomes compared to conventional methods. Additionally, their well-characterized background provides a consistent basis for cross-comparison with other gene modification models, enhancing the validity of research findings.

For researchers and clinicians seeking to explore the complex interactions of the AIFM2 gene, these knockout cell lines represent an invaluable resource. They empower users to advance their understanding of mitochondrial functions and related pathologies effectively, potentially leading to groundbreaking therapeutic strategies.

Our company specializes in providing high-quality biological products, including expertly developed gene knockout models, aiming to support the scientific community with reliable tools for groundbreaking research and transformative clinical applications.

Please note that all services are for research use only. Not intended for any clinical use.

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