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AGTRAP Knockout Cell Lines

Gene: AGTRAP

Official Full Name: angiotensin II receptor associated proteinprovided by HGNC

Gene Summary: This gene encodes a transmembrane protein localized to the plasma membrane and perinuclear vesicular structures. The gene product interacts with the angiotensin II type I receptor and negatively regulates angiotensin II signaling. Alternative splicing of this gene generates multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19924 AGTRAP Knockout cell line (HeLa) Human AGTRAP 1:3~1:6 Negative Online Inquiry
KO19925 AGTRAP Knockout cell line (HCT 116) Human AGTRAP 1:2~1:4 Negative Online Inquiry
KO19926 AGTRAP Knockout cell line (HEK293) Human AGTRAP 1:3~1:6 Negative Online Inquiry
KO19927 AGTRAP Knockout cell line (A549) Human AGTRAP 1:3~1:4 Negative Online Inquiry

Background

AGTRAP Gene Knockout Cell Lines are specialized human or animal cell lines that have been genetically modified to disrupt the expression of the angiotensin II receptor-associated protein (AGTRAP). This innovative product serves as a vital tool in biological research, particularly in the fields of cardiovascular and renal biology, where AGTRAP is known to play a critical role in angiotensin II signaling pathways that influence blood pressure regulation and fluid homeostasis.

At their core, these knockout cell lines utilize CRISPR-Cas9 technology to achieve precise gene disruption, leading to the ablation of AGTRAP expression. This allows researchers to study the physiological effects and downstream signaling cascades resulting from the absence of AGTRAP, providing insights into its role in health and disease. The mechanisms underlying cardiovascular diseases, hypertension, and metabolic disorders can be more fully understood through the lens of these modified cell lines, facilitating the development of novel therapeutics.

The scientific importance of AGTRAP Gene Knockout Cell Lines lies in their applications for drug discovery, toxicology assessments, and mechanisms of disease research. By enabling studies that elucidate the functions of AGTRAP and its interactions with other cellular pathways, these cell lines can accelerate scientific advancements, ultimately contributing to improved clinical strategies for managing related conditions.

What sets AGTRAP Gene Knockout Cell Lines apart from alternative models is their specificity and reproducibility. Unlike traditional siRNA or chemical inhibition methods, these knockout cell lines maintain a stable and lasting disruption of the gene in question, minimizing variability and providing consistent results across experiments. This reliability is crucial for researchers seeking to validate hypotheses or screen compounds with therapeutic potential.

Researchers and clinicians looking to deepen their understanding of AGTRAP's role in cardiovascular function will find exceptional value in these cell lines. They offer an unparalleled opportunity to investigate the molecular underpinnings of disease states and explore innovative treatment options.

With a commitment to advancing biomedical research, our company specializes in providing high-quality biological research tools tailored to meet the demands of modern science. Our AGTRAP Gene Knockout Cell Lines embody our dedication to empowering researchers in their quest for discovery.

Please note that all services are for research use only. Not intended for any clinical use.

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