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AGK Knockout Cell Lines

Gene: AGK

Official Full Name: acylglycerol kinaseprovided by HGNC

Gene Summary: The protein encoded by this gene is a mitochondrial membrane protein involved in lipid and glycerolipid metabolism. The encoded protein is a lipid kinase that catalyzes the formation of phosphatidic and lysophosphatidic acids. Defects in this gene have been associated with mitochondrial DNA depletion syndrome 10. [provided by RefSeq, Feb 2012]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19936 AGK Knockout cell line (HeLa) Human AGK 1:3~1:6 Negative Online Inquiry
KO19937 AGK Knockout cell line (HCT 116) Human AGK 1:2~1:4 Negative Online Inquiry
KO19938 AGK Knockout cell line (HEK293) Human AGK 1:3~1:6 Negative Online Inquiry
KO19939 AGK Knockout cell line (A549) Human AGK 1:3~1:4 Negative Online Inquiry

Background

AGK Gene Knockout Cell Lines represent a cutting-edge tool developed to facilitate research into gene function and regulation. These specialized cell lines have undergone targeted genetic alterations resulting in the knockout of the AGK (Acylglycerol Kinase) gene, which is essential in lipid metabolism and cellular energy homeostasis. This gene knockdown creates an invaluable platform for studying the downstream effects of AGK inhibition on various biological pathways.

Functionally, AGK Gene Knockout Cell Lines allow researchers to investigate the role of AGK in cellular processes such as apoptosis, inflammation, and the regulation of lipid droplet dynamics. By creating a controlled genetic environment devoid of AGK activity, scientists can elucidate the molecular mechanisms behind lipid dysregulation in diseases like obesity, diabetes, and cardiovascular disorders. The precise mechanistic studies facilitated by these knockout lines pave the way for potential therapeutic targets.

The scientific significance of AGK Gene Knockout Cell Lines is underscored by their wide-ranging applications in both basic research and clinical contexts, including drug discovery and toxicology assessments. They provide a robust model for evaluating the impact of AGK modulation on cell viability, metabolic processes, and response to pharmacological agents.

What sets AGK Gene Knockout Cell Lines apart from traditional cellular models is their specificity and reliability. Unlike non-targeted approaches, these lines offer a clean genetic background, ensuring that observed effects can be directly attributed to AGK loss. This specificity delivers higher reproducibility and clarity in experimental outcomes, making it easier for researchers to compile solid, publishable data.

For researchers and clinicians focused on metabolic disorders, the ability to study AGK's role in lipid metabolism can lead to breakthroughs in understanding disease mechanisms and developing targeted therapies. Our expertise in producing and characterizing these knockout models positions us as a leading supplier of biological tools that empower scientific discovery and innovation. Additionally, we offer comprehensive support and resources to maximize the effectiveness of your research using AGK Gene Knockout Cell Lines.

Please note that all services are for research use only. Not intended for any clinical use.

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