Gene: AGBL5
Official Full Name: AGBL carboxypeptidase 5provided by HGNC
Gene Summary: This gene encodes a metallocarboxypeptidase involved in protein deglutamylation and a member of the peptidase M14 family of proteins. The encoded protein has been described as a "dual-functional" deglutamylase that can remove glutamate residues from both carboxyl termini and side chains of protein substrates. This deglutamylase activity may be important in antiviral immunity. Mutations in this gene are associated with retinitis pigmentosa. [provided by RefSeq, Jul 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19943 | AGBL5 Knockout cell line (HeLa) | Human | AGBL5 | 1:3~1:6 | Negative | Online Inquiry |
KO19944 | AGBL5 Knockout cell line (HCT 116) | Human | AGBL5 | 1:2~1:4 | Negative | Online Inquiry |
KO19945 | AGBL5 Knockout cell line (HEK293) | Human | AGBL5 | 1:3~1:6 | Negative | Online Inquiry |
KO19946 | AGBL5 Knockout cell line (A549) | Human | AGBL5 | 1:3~1:4 | Negative | Online Inquiry |
AGBL5 Gene Knockout Cell Lines represent a significant advancement in the field of genetic research, designed to study the functional role of the AGBL5 gene in cellular mechanisms. These cell lines are engineered using CRISPR-Cas9 technology to create precise deletions in the AGBL5 gene, enabling scientists to investigate its contributions to various biological processes, including microtubule dynamics, intracellular transport, and cellular response to stress.
The knockout mechanism effectively disables the gene's expression, allowing researchers to observe phenotypic changes and molecular pathways influenced by AGBL5. This functionality provides crucial insights into its role in pathologies such as cancer, neurodegenerative disorders, and metabolic diseases, making these cell lines invaluable for both basic and applied research.
Scientifically, AGBL5 gene knockout cell lines expand the toolbox for gene function analysis and drug discovery, facilitating high-throughput screening methods and validation of targets for therapeutic intervention. They stand apart from other available models by offering a unique, reliable platform that mirrors the complexity of human disease states, thanks to their human-derived origin.
Additionally, these cell lines provide distinct advantages, such as enhanced reproducibility and the ability to study gene-environment interactions in vitro. By utilizing AGBL5 knockout lines, researchers and clinicians can gain deeper mechanistic insights and develop innovative treatment strategies that were previously inaccessible.
Our company is dedicated to advancing life sciences through the creation of high-quality research tools, underpinned by our expertise in gene editing and cell line development. With our AGBL5 Gene Knockout Cell Lines, you will be equipped to push the boundaries of discovery and enhance your research outcomes.
Please note that all services are for research use only. Not intended for any clinical use.
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