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AFF2 Knockout Cell Lines

Gene: AFF2

Official Full Name: ALF transcription elongation factor 2provided by HGNC

Gene Summary: This gene encodes a putative transcriptional activator that is a member of the AF4\FMR2 gene family. This gene is associated with the folate-sensitive fragile X E locus on chromosome X. A repeat polymorphism in the fragile X E locus results in silencing of this gene causing Fragile X E syndrome. Fragile X E syndrome is a form of nonsyndromic X-linked cognitive disability. In addition, this gene contains 6-25 GCC repeats that are expanded to >200 repeats in the disease state. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Jul 2016]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO37840 AFF2 Knockout cell line (HEK293) Human AFF2 1:3~1:6 Negative Online Inquiry

Background

AFF2 Gene Knockout Cell Lines are meticulously engineered biological tools designed for the comprehensive study of the AFF2 gene and its role in cellular functions. These cell lines are created through the targeted deletion of the AFF2 gene, utilizing advanced CRISPR/Cas9 gene editing techniques. By knocking out AFF2, researchers can investigate the gene's involvement in various biological pathways, offering insights into alternative splicing mechanisms, gene regulation, and the molecular underpinnings of related disorders.

The primary mechanism of these cell lines involves the disruption of the AFF2 gene's expression, allowing for the study of phenotypic changes and alterations in cellular behavior. As AFF2 is associated with multiple neurological disorders and intellectual disabilities, these knockout models enable researchers to elucidate disease mechanisms and explore potential therapeutic interventions. The versatility of these cell lines makes them invaluable in both basic research settings and drug discovery processes.

In the competitive landscape of genetic research tools, AFF2 Gene Knockout Cell Lines stand out due to their specificity and reliability. Unlike conventional methods that may produce heterogeneous results, our engineered cell lines provide consistent performance and reproducibility, allowing researchers to generate statistically robust data. Furthermore, they can be easily adapted for high-throughput screening, which is a crucial advantage for pharmaceutical applications.

The value of AFF2 Gene Knockout Cell Lines lies in their potential to empower researchers and clinicians in understanding and addressing complex genetic disorders. By providing a precise model for the investigation of AFF2-related functions, these cell lines facilitate the development of targeted therapies and innovative treatment strategies.

Our commitment to excellence in biotechnological advancements ensures that you receive top-tier products. With a robust background in genetic engineering and a focus on quality, our company is dedicated to supporting scientific discovery through exceptional research tools tailored to meet contemporary needs.

Please note that all services are for research use only. Not intended for any clinical use.

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