Gene: AEN
Official Full Name: apoptosis enhancing nucleaseprovided by HGNC
Gene Summary: Enables DNA exonuclease activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and response to ionizing radiation. Located in nuclear membrane; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2025]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO19965 | AEN Knockout cell line (HeLa) | Human | AEN | 1:3~1:6 | Negative | Online Inquiry |
KO19966 | AEN Knockout cell line (HCT 116) | Human | AEN | 1:2~1:4 | Negative | Online Inquiry |
KO19967 | AEN Knockout cell line (HEK293) | Human | AEN | 1:3~1:6 | Negative | Online Inquiry |
KO19968 | AEN Knockout cell line (A549) | Human | AEN | 1:3~1:4 | Negative | Online Inquiry |
AEN Gene Knockout Cell Lines are precision-engineered cellular models that facilitate the functional analysis of specific genes by abrogating their expression. These cell lines are developed using state-of-the-art CRISPR/Cas9 technology, which allows for precise and efficient gene editing, enabling researchers to create specific knockout models that elucidate gene function and its implications in various biological processes.
The key function of AEN Gene Knockout Cell Lines lies in their ability to mimic disease states and study phenotype alterations resulting from gene loss. The CRISPR/Cas9 system introduces targeted double-strand breaks in the genomic DNA, leading to a loss of function through insertions or deletions in the target gene. Researchers can observe the subsequent biological outcomes, which allows for improved understanding of gene interactions, protein functions, and metabolic pathways. These insights are crucial for identifying potential therapeutic targets and validating drug responses.
In both research and clinical settings, AEN Gene Knockout Cell Lines serve as invaluable tools for cancer research, genetic disorder modeling, and drug discovery, providing scientists with the capability to study gene functions in a controlled environment. Their reproducibility and genetic integrity make them superior options compared to traditional knockout methods, which often suffer from lengthy creation times and unpredictable genetic backgrounds.
One significant advantage of the AEN Gene Knockout Cell Lines is the broad range of pre-established cell types available, spanning various tissues and disease models that enable researchers to select the most relevant options for their studies. Additionally, these cell lines come with comprehensive support and validation data, which enhances user confidence in experimental design and outcome predictability.
The value of AEN Gene Knockout Cell Lines lies in their capacity to accelerate basic and translational research, providing vital insights that can inform therapeutic strategies and enhance our understanding of complex genetic landscapes. By leveraging our deep expertise in gene editing technologies and biological research, our company is committed to empowering scientists and clinicians with tools that drive the next generation of biomedical discoveries.
Please note that all services are for research use only. Not intended for any clinical use.
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