Gene: ADSS1
Official Full Name: adenylosuccinate synthase 1provided by HGNC
Gene Summary: This gene encodes a member of the adenylosuccinate synthase family of proteins. The encoded muscle-specific enzyme plays a role in the purine nucleotide cycle by catalyzing the first step in the conversion of inosine monophosphate (IMP) to adenosine monophosphate (AMP). Mutations in this gene may cause adolescent onset distal myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO28906 | ADSS1 Knockout cell line (HeLa) | Human | ADSS1 | 1:3~1:6 | Negative | Online Inquiry |
KO28907 | ADSS1 Knockout cell line (HCT 116) | Human | ADSS1 | 1:2~1:4 | Negative | Online Inquiry |
KO28908 | ADSS1 Knockout cell line (A549) | Human | ADSS1 | 1:3~1:4 | Negative | Online Inquiry |
ADSS1 Gene Knockout Cell Lines are specialized cell lines generated through the precise editing of the ADSS1 gene, which encodes for adenylosuccinate synthase, an important enzyme in the de novo purine nucleotide synthesis pathway. These knockout cell lines serve as invaluable research tools for understanding the biological ramifications of ADSS1 gene disruption, enabling scientists to investigate cellular metabolism, gene function, and disease mechanisms in a controlled environment.
The primary function of ADSS1 Gene Knockout Cell Lines is to provide a model for studying the impact of ADSS1 deficiency on cellular processes. By eliminating the expression of this gene, researchers can observe alterations in purine metabolism, energy balance, and related signaling pathways. This allows for a deeper understanding of conditions such as metabolic disorders, neurodevelopmental diseases, and cancer, where aberrations in nucleotide synthesis may play a critical role.
The scientific importance of ADSS1 Gene Knockout Cell Lines is underscored by their utility in both basic research and clinical applications. These cell lines facilitate drug discovery efforts and serve as platforms for evaluating therapeutic interventions aimed at restoring normal adenine nucleotide biosynthesis. Moreover, they can be employed in studies examining the biochemical cascade leading to potential pathologies associated with ADSS1 dysfunction.
What sets ADSS1 Gene Knockout Cell Lines apart from other models is their high specificity and reliability. Other knockout models may introduce off-target effects or fail to mimic the complexity of human disease states accurately. In contrast, our ADSS1 cell lines are rigorously validated for gene deletion and phenotype consistency, ensuring that researchers obtain reproducible and relevant results.
For researchers and clinicians, the value of ADSS1 Gene Knockout Cell Lines lies in their role as robust tools for translational research and therapeutic development. By providing clarity on the functional aspects of the ADSS1 gene, these cell lines support innovative strategies for tackling metabolic and genetic disorders.
Our company prides itself on its commitment to advancing biological research through high-quality products such as the ADSS1 Gene Knockout Cell Lines, backed by a team of experts in genetic engineering and cell biology. By choosing our products, you benefit from years of expertise and dedication to excellence in the life sciences field.
Please note that all services are for research use only. Not intended for any clinical use.
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