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ADORA1 Knockout Cell Lines

Gene: ADORA1

Official Full Name: adenosine A1 receptorprovided by HGNC

Gene Summary: The protein encoded by this gene is an adenosine receptor that belongs to the G-protein coupled receptor 1 family. There are 3 types of adenosine receptors, each with a specific pattern of ligand binding and tissue distribution, and together they regulate a diverse set of physiologic functions. The type A1 receptors inhibit adenylyl cyclase, and play a role in the fertilization process. Animal studies also suggest a role for A1 receptors in kidney function and ethanol intoxication. Transcript variants with alternative splicing in the 5' UTR have been found for this gene. [provided by RefSeq, Jul 2008]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO07620 ADORA1 Knockout cell line (HCT 116) Human ADORA1 1:2~1:4 Negative Online Inquiry
KO07621 ADORA1 Knockout cell line (HEK293) Human ADORA1 1:3~1:6 Negative Online Inquiry
KO07622 ADORA1 Knockout cell line (A549) Human ADORA1 1:3~1:4 Negative Online Inquiry

Background

ADORA1 Gene Knockout Cell Lines are specialized cellular models engineered to disrupt the function of the Adenosine A1 receptor (ADORA1), a significant component in various physiological processes such as cardiac function, neuroprotection, and metabolic regulation. By utilizing the CRISPR/Cas9 gene editing technology, these knockout cell lines provide an invaluable tool for researchers to study the role of ADORA1 in cellular signal transduction pathways and its implications in both health and disease.

The primary function of ADORA1 Gene Knockout Cell Lines is to allow scientists to investigate the phenotypic and molecular consequences of ADORA1 deficiency. This aids in elucidating the receptor's influence on various cellular behaviors, such as proliferation, apoptosis, and response to therapeutic agents. These cell lines enable functional assays and high-throughput screening processes that examine the receptor's involvement in different signaling cascades, thereby providing insights pertinent to cardiovascular diseases, cancer biology, and neurodegenerative disorders.

From a scientific perspective, ADORA1 knockout models are critical in expanding our understanding of adenosine signaling dynamics in both in vitro and in vivo contexts. In a clinical research setting, these cell lines can serve as platforms for drug discovery, helping identify potential therapeutic targets and evaluating the efficacy of adenosine receptor modulators. Researchers can confidently leverage these models for translational studies, which could lead to novel treatment options for conditions associated with dysregulated adenosine signaling.

The distinct advantages of ADORA1 Gene Knockout Cell Lines include their high specificity and reproducibility, enabling researchers to obtain consistent results. Compared to alternative models, these cell lines support enhanced manipulation of gene function, which is vital for dissecting complex interaction networks. Furthermore, they provide a robust foundation for understanding therapeutic interventions that could mitigate receptor-related pathologies.

In summary, ADORA1 Gene Knockout Cell Lines are a compelling asset for researchers and clinicians focused on the multifaceted roles of adenosine signaling. Our company prides itself on its commitment to quality and innovation in producing reliable biological products. With extensive expertise in cell line development and gene editing technologies, we offer products tailored to advance your research initiatives and enrich your clinical pursuits.

Please note that all services are for research use only. Not intended for any clinical use.

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