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ADI1 Knockout Cell Lines

Gene: ADI1

Official Full Name: acireductone dioxygenase 1provided by HGNC

Gene Summary: This gene encodes an enzyme that belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization. Related pseudogenes have been defined on chromosomes 8 and 20. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO19982 ADI1 Knockout cell line (HeLa) Human ADI1 1:3~1:6 Negative Online Inquiry
KO19983 ADI1 Knockout cell line (HCT 116) Human ADI1 1:2~1:4 Negative Online Inquiry
KO19984 ADI1 Knockout cell line (HEK293) Human ADI1 1:3~1:6 Negative Online Inquiry
KO19985 ADI1 Knockout cell line (A549) Human ADI1 1:3~1:4 Negative Online Inquiry

Background

ADI1 Gene Knockout Cell Lines are engineered cellular models in which the ADI1 gene, which encodes for the enzyme activated during the regulation of ammonia and amino acid levels in the cell, has been deliberately disrupted. This technical approach involves CRISPR-Cas9 gene editing technology, ensuring precise alterations within the genome to facilitate the study of ADI1's functions and its role in various biological processes.

The key functions of ADI1 include its involvement in the urea cycle and its role in the detoxification of ammonia, which is crucial for cellular health. By employing ADI1 gene knockout cell lines, researchers can investigate the repercussions of gene loss on cellular metabolism, explore pathways involved in neurological disorders, and comprehend the mechanisms underlying conditions associated with amino acid dysregulation. The perturbation of the ADI1 gene provides a unique lens for studying metabolic diseases, neurodegenerative conditions, and the general cellular response to elevated ammonia levels, thus offering insights that could lead to novel therapeutic approaches.

The scientific importance of these cell lines cannot be overstated. They serve as invaluable tools in both fundamental research and clinical applications, enhancing our understanding of metabolic pathways and providing a platform for drug discovery. In comparison to traditional cell lines, the ADI1 knockout model allows for more refined investigations into gene function and disease modeling, providing a clear advantage in specificity and accuracy.

For researchers and clinicians, the value of ADI1 Gene Knockout Cell Lines lies in their ability to deliver reproducible, relevant data that can accelerate the pace of discovery. By using these cell lines, scientists can create targeted studies that pinpoint the roles and implications of the ADI1 gene in health and disease.

Our company stands at the forefront of biological product innovation, specializing in high-quality genomic models that empower researchers to unlock the complexities of gene regulation and pave the way for advancements in precision medicine. Our expertise ensures that each product, including ADI1 Gene Knockout Cell Lines, is built with precision and reliability, supporting transformative research in a myriad of scientific fields.

Please note that all services are for research use only. Not intended for any clinical use.

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