Gene: ADGRB2
Official Full Name: adhesion G protein-coupled receptor B2provided by HGNC
Gene Summary: This gene encodes a a seven-span transmembrane protein that is thought to be a member of the secretin receptor family. The encoded protein is a brain-specific inhibitor of angiogenesis. The mature peptide may be further cleaved into additional products (PMID:20367554). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO38852 | ADGRB2 Knockout cell line (HeLa) | Human | ADGRB2 | 1:3~1:6 | Negative | Online Inquiry |
KO38853 | ADGRB2 Knockout cell line (HCT 116) | Human | ADGRB2 | 1:2~1:4 | Negative | Online Inquiry |
KO38854 | ADGRB2 Knockout cell line (HEK293) | Human | ADGRB2 | 1:3~1:6 | Negative | Online Inquiry |
KO38855 | ADGRB2 Knockout cell line (A549) | Human | ADGRB2 | 1:3~1:4 | Negative | Online Inquiry |
ADGRB2 Gene Knockout Cell Lines are genetically engineered cell models that have been designed to facilitate the study of the ADGRB2 gene, which encodes for the adhesion G protein-coupled receptor B2. This essential receptor plays a significant role in cell adhesion processes, cellular signaling, and impacts numerous physiological and pathological conditions, including cancer, cardiovascular diseases, and neurological disorders. The knockout of ADGRB2 enables researchers to dissect the functional roles of this receptor, promoting deeper understanding of various biological pathways.
The key function of these knockout cell lines lies in their ability to eliminate the expression of the ADGRB2 gene, thus providing a controlled environment to assess the downstream effects of its absence. Researchers can investigate changes in cell proliferation, migration, and signaling pathways that are affected by ADGRB2, elucidating its contributions to cellular behavior. The mechanisms underlying these phenotypic changes can be further explored using complementing techniques such as transcriptomic analysis or proteomics.
The scientific importance of ADGRB2 Gene Knockout Cell Lines extends to both research and clinical settings. For researchers, these models are invaluable for drug discovery and development, as they allow for the identification of novel therapeutic targets. In clinical contexts, understanding ADGRB2 function can lead to innovations in the treatment of diseases where this receptor is implicated, thus translating basic scientific insights into therapeutic avenues.
Compared to native cell lines or alternative knockout models, ADGRB2 Gene Knockout Cell Lines stand out due to their targeted nature, ensuring specificity in gene disruption while maintaining the integrity of other genes within the genome. This precision allows for clearer insights into ADGRB2's role, minimizing off-target effects that can confound results in less characterized models.
Researchers, clinicians, and pharmaceutical developers will find tremendous value in ADGRB2 Gene Knockout Cell Lines for advancing their understanding of receptor biology and its implications in disease. By utilizing these specialized models, they can glean insights that drive both basic and applied research forward.
With extensive expertise in the development of innovative biological products, our company is committed to providing high-quality, reliable tools that empower scientists to unlock the complexities of cellular and molecular mechanisms, ultimately fostering advancements in science and health care.
Please note that all services are for research use only. Not intended for any clinical use.
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