Gene: ADAMTS7
Official Full Name: ADAM metallopeptidase with thrombospondin type 1 motif 7provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO31129 | ADAMTS7 Knockout cell line (HeLa) | Human | ADAMTS7 | 1:3~1:6 | Negative | Online Inquiry |
KO31130 | ADAMTS7 Knockout cell line (HCT 116) | Human | ADAMTS7 | 1:2~1:4 | Negative | Online Inquiry |
KO31131 | ADAMTS7 Knockout cell line (HEK293) | Human | ADAMTS7 | 1:3~1:6 | Negative | Online Inquiry |
KO31132 | ADAMTS7 Knockout cell line (A549) | Human | ADAMTS7 | 1:3~1:4 | Negative | Online Inquiry |
ADAMTS7 Gene Knockout Cell Lines are customized cell models developed through advanced CRISPR-Cas9 gene editing technology, specifically designed to study the function of the ADAMTS7 gene, which encodes a member of the a disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS) family. These cell lines allow researchers to investigate the role of ADAMTS7 in various biological processes, including extracellular matrix remodeling, inflammation, and disease progression, particularly in cardiovascular conditions.
The primary mechanism by which these knockout cell lines function is through the targeted deletion of the ADAMTS7 gene, effectively silencing its expression and enabling the assessment of downstream effects on cellular pathways. As a result, researchers can elucidate the gene’s contribution to the pathophysiology of diseases, cellular behaviors, and molecular interactions. The applications of ADAMTS7 knockout cell lines are vast, encompassing fundamental research to elucidate gene function, pharmacological studies to identify potential drug targets, and translational research aimed at developing therapeutic interventions.
One of the distinguishing advantages of using ADAMTS7 Gene Knockout Cell Lines over traditional methods is the precision of the CRISPR-Cas9 technology, which yields reproducible results and minimizes off-target effects. Furthermore, these cell lines come with thorough validation, ensuring that researchers receive a reliable tool for their studies. Another notable feature is the scalability these lines provide, which makes them suitable for high-throughput screening, allowing for large-scale experimentation.
For researchers, clinicians, and pharmaceutical professionals, ADAMTS7 Gene Knockout Cell Lines represent an invaluable resource in the quest to understand complex biological systems and develop targeted therapies. Leveraging these models can lead to significant breakthroughs in the management of diseases associated with ADAMTS7 dysfunction.
As a leader in the development of innovative biological products, our company is dedicated to providing high-quality science-driven solutions that empower researchers and clinicians in their pursuit of groundbreaking findings and treatments. Our expertise in gene editing and commitment to advancing biological research position us as a trusted partner in the scientific community.
Please note that all services are for research use only. Not intended for any clinical use.
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