Gene: ADAM15
Official Full Name: ADAM metallopeptidase domain 15provided by HGNC
Gene Summary: The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as a EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Catalog Number | Product Name | Species | Gene | Passage ratio | Mycoplasma testing | Price |
---|---|---|---|---|---|---|
KO33896 | ADAM15 Knockout cell line (HeLa) | Human | ADAM15 | 1:3~1:6 | Negative | Online Inquiry |
KO33897 | ADAM15 Knockout cell line (HCT 116) | Human | ADAM15 | 1:2~1:4 | Negative | Online Inquiry |
KO33898 | ADAM15 Knockout cell line (HEK293) | Human | ADAM15 | 1:3~1:6 | Negative | Online Inquiry |
KO33899 | ADAM15 Knockout cell line (A549) | Human | ADAM15 | 1:3~1:4 | Negative | Online Inquiry |
ADAM15 Gene Knockout Cell Lines are genetically engineered cell lines that have been specifically modified to carry a knockout of the ADAM15 (A Disintegrin And Metalloproteinase 15) gene. This product is vital for researchers who are investigating the role of ADAM15 in various biological processes, including cell adhesion, migration, and signaling pathways in cancer metastasis and tissue repair.
These cell lines function via the precise deletion of the ADAM15 gene through CRISPR-Cas9 technology, allowing for the elimination of the protein’s activity. As a consequence, researchers can study the downstream effects of ADAM15 knockout, providing insights into its involvement in pathological conditions such as inflammation, cardiovascular diseases, and malignancies. By utilizing these knockout cell lines, scientists can uncover novel therapeutic targets and elucidate the mechanistic pathways associated with ADAM15.
The scientific importance of ADAM15 Gene Knockout Cell Lines is underscored by their application in both fundamental research and clinical settings. They serve as invaluable tools in drug discovery and development, enabling the screening of potential inhibitors and the assessment of treatment efficacy in ADAM15-related diseases. Moreover, these cell lines facilitate the study of cellular responses to therapies, offering a robust platform for understanding patient-specific treatment outcomes.
Compared to conventional methods of gene manipulation, such as RNA interference, ADAM15 Gene Knockout Cell Lines provide a more permanent and thorough gene alteration, leading to more reliable experimental results. This durability is a significant advantage, allowing researchers to observe long-term phenotypic changes without the variability associated with transient knockdown approaches.
By utilizing these knockout cell lines, researchers and clinicians can gain a deeper understanding of ADAM15 biology, presenting opportunities for advancing therapeutic strategies and improving patient care. Our company’s expertise in genetic engineering and commitment to quality assurance make our ADAM15 Gene Knockout Cell Lines a reliable choice for researchers aiming to push the boundaries of biomedical science. We are dedicated to providing cutting-edge tools that empower scientific discovery and foster innovation in the field.
Please note that all services are for research use only. Not intended for any clinical use.
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