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ADAM12 Knockout Cell Lines

Gene: ADAM12

Official Full Name: ADAM metallopeptidase domain 12provided by HGNC

Gene Summary: This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]

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Products Background

Products

Catalog Number Product Name Species Gene Passage ratio Mycoplasma testing Price
KO00298 ADAM12 Knockout cell line (HCT 116) Human ADAM12 1:2~1:4 Negative Online Inquiry
KO03371 ADAM12 Knockout cell line (HeLa) Human ADAM12 1:3~1:6 Negative Online Inquiry
KO03372 ADAM12 Knockout cell line (A549) Human ADAM12 1:3~1:4 Negative Online Inquiry

Background

ADAM12 Gene Knockout Cell Lines are genetically engineered cell lines that lack functional expression of the ADAM12 gene, which encodes a member of the disintegrin and metalloproteinase (ADAM) family. This innovative product serves as a powerful tool in biological research, specifically for the study of cell signaling pathways, muscle development, and tissue regeneration. By knocking out the ADAM12 gene, researchers can investigate the gene's role in various physiological and pathological contexts, providing insights into its involvement in diseases such as muscular dystrophy, cancer metastasis, and inflammation.

The mechanism of action relies on CRISPR-Cas9 technology, which allows for precise edits in the genomic sequence of the cell lines. The resulting cell lines enable the examination of ADAM12’s functional roles by providing a controlled environment in which scientists can assess cellular behaviors, protein interactions, and downstream effects related to the absence of this particular gene. This creates a strong basis for hypothesis-driven research and can foster the development of targeted therapeutic strategies.

The scientific importance of ADAM12 Gene Knockout Cell Lines lies in their ability to improve our understanding of cell biology and the molecular mechanisms underlying various diseases. They serve as essential models in both in vitro and in vivo studies, facilitating drug discovery, biomarker identification, and the evaluation of treatment modalities.

When compared to alternative products, ADAM12 Gene Knockout Cell Lines offer remarkable specificity and reliability. Their production involves rigorous validation processes, ensuring consistent performance across experiments. This high level of reproducibility is crucial for scientific studies where slight variations can impact results, thereby enhancing the credibility of research findings.

For researchers and clinicians, the value of these cell lines is indisputable. They provide a unique and efficient approach to dissect complex biological questions and validate potential therapeutic targets. Moreover, by using these advanced cell lines, users gain a competitive edge in their research endeavors.

Our company excels in the development of innovative biological products, grounded in cutting-edge genomic technologies. With a commitment to quality and integrity, we strive to empower researchers and clinicians in their pursuit of groundbreaking discoveries and clinical advancements.

Please note that all services are for research use only. Not intended for any clinical use.

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